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anti-LILRB2 antibody :: Rabbit anti-Human LILRB2 Polyclonal Antibody

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Catalog # MBS2529359
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

LILRB2, Polyclonal Antibody

Popular Item
Full Product Name

LILRB2 Polyclonal Antibody

Product Synonym Names
ILT4, LIR2, CD85D, LIR-2, MIR10, LILRA6, MIR-10
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2529359 MSDS
MBS2529359 Technical Datasheet
OMIM
604815
3D Structure
ModBase 3D Structure for BC036827
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human LILRB2
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LILRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LILRB2 antibody
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. 4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-LILRB2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-LILRB2 antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-LILRB2 antibody
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using LILRB2 Polyclonal Antibody at dilution 1:30
anti-LILRB2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LILRB2 antibody
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using LILRB2 Polyclonal Antibody at dilution 1:30
anti-LILRB2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LILRB2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 5
NCBI Official Synonym Full Names
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
NCBI Official Symbol
LILRB2  [Similar Products]
NCBI Official Synonym Symbols
ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10
  [Similar Products]
NCBI Protein Information
leukocyte immunoglobulin-like receptor subfamily B member 2; CD85 antigen-like family member D; Ig-like transcript 4; monocyte/macrophage immunoglobulin-like receptor 10
UniProt Protein Name
Leukocyte immunoglobulin-like receptor subfamily B member 2
UniProt Synonym Protein Names
CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD_antigen: CD85d
UniProt Gene Name
LILRB2  [Similar Products]
UniProt Synonym Gene Names
ILT4; LIR2; MIR10; LIR-2; Leukocyte immunoglobulin-like receptor 2; ILT-4; MIR-10  [Similar Products]
UniProt Entry Name
LIRB2_HUMAN
NCBI Summary for LILRB2
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for LILRB2
LILRB2: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; MHC class I protein binding; cell adhesion molecule binding; receptor activity; protein phosphatase 1 binding; inhibitory MHC class I receptor activity

Biological Process: immune response-inhibiting cell surface receptor signaling pathway; negative regulation of calcium ion transport; regulation of immune response; positive regulation of regulatory T cell differentiation; negative regulation of immune response; positive regulation of interleukin-6 production; signal transduction; positive regulation of tolerance induction; heterotypic cell-cell adhesion; negative regulation of T cell proliferation; cell surface receptor linked signal transduction; cell-cell signaling; negative regulation of antigen processing and presentation; cellular defense response; Fc receptor mediated inhibitory signaling pathway; immune response; positive regulation of T cell proliferation; positive regulation of T cell tolerance induction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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