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anti-LMBRD1 antibody :: Rabbit anti-Human LMBRD1 Polyclonal Antibody

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Catalog # MBS7004297
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

LMBRD1, Polyclonal Antibody

Popular Item
Also Known As

LMBRD1 Antibody

Product Synonym Names
Probable lysosomal cobalamin transporter; HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein; LMBRD1; C6orf209; NESI; BM-021; CD001; MSTP044
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
540
OMIM
277380
3D Structure
ModBase 3D Structure for Q9NUN5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human Probable lysosomal cobalamin transporter protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LMBRD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LMBRD1 antibody
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
Applications Tested/Suitable for anti-LMBRD1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-LMBRD1 antibody
Western Blot
Positive WB detected in:Mouse liver tissue,Mouse kidney tissue
All lanes: LMBRD1 antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 62,45,54,22 kDa
Observed band size: 62,54 kDa

anti-LMBRD1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-LMBRD1 antibody
Immunohistochemistry of paraffin-embedded human brain tissue using MBS7004297 at dilution of 1:100
anti-LMBRD1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LMBRD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,394 Da
NCBI Official Full Name
probable lysosomal cobalamin transporter
NCBI Official Synonym Full Names
LMBR1 domain containing 1
NCBI Official Symbol
LMBRD1  [Similar Products]
NCBI Official Synonym Symbols
NESI; LMBD1; MAHCF; C6orf209
  [Similar Products]
NCBI Protein Information
probable lysosomal cobalamin transporter
UniProt Protein Name
Probable lysosomal cobalamin transporter
UniProt Synonym Protein Names
HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein
UniProt Gene Name
LMBRD1  [Similar Products]
UniProt Synonym Gene Names
C6orf209; NESI  [Similar Products]
UniProt Entry Name
LMBD1_HUMAN
NCBI Summary for LMBRD1
This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]
UniProt Comments for LMBRD1
LMBRD1: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAHCF). A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12. Belongs to the LIMR family. LMBRD1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: clathrin-coated endocytic vesicle; integral to membrane; lysosomal membrane; membrane; plasma membrane

Molecular Function: cobalamin binding; insulin receptor binding

Biological Process: cobalamin metabolic process; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; negative regulation of protein kinase B signaling cascade; viral reproduction; vitamin metabolic process; water-soluble vitamin metabolic process

Disease: Methylmalonic Aciduria And Homocystinuria, Cblf Type
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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