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anti-LMNB1 antibody :: Rabbit anti-Human LMNB1 Polyclonal Antibody

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Catalog # MBS7049551
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

LMNB1, Polyclonal Antibody

Popular Item
Also Known As

LMNB1 Antibody

Product Synonym Names
Lamin-B1; LMNB1; LMN2; LMNB
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
586
OMIM
M34458 mRNA
3D Structure
ModBase 3D Structure for P20700
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human Lamin-B1 protein (385-552AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30264 / sc-6217 / sc-6216 / sc-20682
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LMNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LMNB1 antibody
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Applications Tested/Suitable for anti-LMNB1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-LMNB1 antibody
IHC: 1: 20-1: 200

Immunohistochemistry (IHC) of anti-LMNB1 antibody
Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7049551 at dilution of 1:100
anti-LMNB1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LMNB1 antibody
Immunohistochemistry of paraffin-embedded human lung cancer using MBS7049551 at dilution of 1:100
anti-LMNB1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LMNB1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,408 Da
NCBI Official Full Name
lamin-B1 isoform 1
NCBI Official Synonym Full Names
lamin B1
NCBI Official Symbol
LMNB1  [Similar Products]
NCBI Official Synonym Symbols
LMN; ADLD; LMN2; LMNB
  [Similar Products]
NCBI Protein Information
lamin-B1
UniProt Protein Name
Lamin-B1
Protein Family
UniProt Gene Name
LMNB1  [Similar Products]
UniProt Synonym Gene Names
LMN2; LMNB  [Similar Products]
UniProt Entry Name
LMNB1_HUMAN
NCBI Summary for LMNB1
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for LMNB1
Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: membrane; nuclear envelope; nuclear membrane; nucleoplasm

Molecular Function: protein binding

Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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