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anti-LPXN antibody :: Rabbit anti-Human LPXN Polyclonal Antibody

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Catalog # MBS7000445
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

LPXN, Polyclonal Antibody

Popular Item
Also Known As

LPXN Antibody

Product Synonym Names
Leupaxin; LPXN; LDLP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
391
OMIM
605390
3D Structure
ModBase 3D Structure for O60711
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human Leupaxin protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-241521 / sc-241524
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LPXN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LPXN antibody
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
Applications Tested/Suitable for anti-LPXN antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-LPXN antibody
Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7000445 at dilution of 1:100
anti-LPXN antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LPXN antibody
Immunohistochemistry of paraffin-embedded human lymph node tissue using MBS7000445 at dilution of 1:100
anti-LPXN antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LPXN antibody
Immunofluorescent analysis of PC3 cells using MBS7000445 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-LPXN antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-LPXN antibody
Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: LPXN antibody at 2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44 KDa
Observed band size: 44 KDa

anti-LPXN antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for LPXN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,750 Da
NCBI Official Full Name
leupaxin isoform 1
NCBI Official Synonym Full Names
leupaxin
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
leupaxin
UniProt Protein Name
Leupaxin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
LPXN_HUMAN
NCBI Summary for LPXN
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
UniProt Comments for LPXN
leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion. .

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: cell projection; cytoplasm; focal adhesion; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome

Molecular Function: protein binding; transcription cofactor activity; zinc ion binding

Biological Process: cell adhesion; negative regulation of B cell receptor signaling pathway; negative regulation of cell adhesion; protein complex assembly; regulation of cell adhesion mediated by integrin; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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