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anti-LRP1 antibody :: Rabbit anti-Human LRP1 Polyclonal Antibody

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Catalog # MBS127416
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Western Blot (WB)
Product Name

LRP1, Polyclonal Antibody

Popular Item
Full Product Name

LRP1 Polyclonal Antibody

Product Synonym Names
APR; LRP; A2MR; CD91; APOER; TGFBR5; IGFBP3R
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
107770
3D Structure
ModBase 3D Structure for Q07954
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purification
Source
Rabbit
Immunogen
Recombinant funsion protein containing a sequence corresponding to amino acids 20-270 of human LRP1 (NP_002323.2).
Calculated MW
31kDa
Observed MW
95 kDa
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-LRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LRP1 antibody
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
Product Categories/Family for anti-LRP1 antibody
Applications Tested/Suitable for anti-LRP1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-LRP1 antibody
WB: 1:500-1:1000

Western Blot (WB) of anti-LRP1 antibody
Western blot analysis of extracts of SH-SY5Y cells, using LRP1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-LRP1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for LRP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Prolow-density lipoprotein receptor-related protein 1
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein 1
NCBI Official Symbol
NCBI Official Synonym Symbols
APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
  [Similar Products]
NCBI Protein Information
prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor
UniProt Protein Name
Prolow-density lipoprotein receptor-related protein 1
UniProt Synonym Protein Names
Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD_antigen: CD91Cleaved into the following 3 chains:Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; LRP-515; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRPICD
UniProt Gene Name
UniProt Synonym Gene Names
A2MR; APR; LRP-1; A2MR; APOER; LRP-85; LRP-515; LRPICD  [Similar Products]
UniProt Entry Name
LRP1_HUMAN
NCBI Summary for LRP1
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
UniProt Comments for LRP1
LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.

Protein type: Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: focal adhesion; cell soma; clathrin-coated vesicle; lysosomal membrane; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; nucleolus; coated pit; endosome; receptor complex

Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; calcium ion binding; receptor activity

Biological Process: positive regulation of protein transport; receptor-mediated endocytosis; cell proliferation; positive regulation of lipid transport; cholesterol metabolic process; phototransduction, visible light; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; lipoprotein metabolic process; negative regulation of neuron apoptosis; negative regulation of smooth muscle cell migration; retinoid metabolic process; regulation of cholesterol transport; apoptotic cell clearance; aging
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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