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anti-LRP2 antibody :: Rabbit anti-Human LRP2 / Megalin Polyclonal Antibody

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Catalog # MBS240863
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Immunohistochemistry (IHC)
Product Name

LRP2 / Megalin, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human LRP2 / Megalin

Product Synonym Names
Anti-LRP2 / Megalin Antibody IHC-plus; LRP2; DBS; Glycoprotein 330; gp330; Megalin; LRP-2; Calcium sensor protein; Human LRP2; Megalin
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
4655
OMIM
phenotype 600073
3D Structure
ModBase 3D Structure for P98164
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Protein G Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human LRP2 / Megalin.
Immunogen Type
Synthetic peptide
Immunogen
LRP2 / Megalin antibody was raised against synthetic peptide from human LRP2 / Megalin.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of anti-LRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LRP2 antibody
Megalin or low density lipoprotein-related protein 2 (LRP2), is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithelial tissues such as the kidney. Megalin has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase.
Applications Tested/Suitable for anti-LRP2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-LRP2 antibody
ELISA (1:000 - 1:1000), IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-LRP2 antibody
Anti-Megalin antibody IHC of human kidney cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-LRP2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LRP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
521,958 Da
NCBI Official Full Name
low-density lipoprotein receptor-related protein 2
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein 2
NCBI Official Symbol
NCBI Official Synonym Symbols
DBS; GP330
  [Similar Products]
NCBI Protein Information
low-density lipoprotein receptor-related protein 2; LRP-2; megalin; glycoprotein 330; calcium sensor protein; Heymann nephritis antigen homolog
UniProt Protein Name
Low-density lipoprotein receptor-related protein 2
UniProt Synonym Protein Names
Glycoprotein 330; gp330; Megalin
UniProt Gene Name
UniProt Synonym Gene Names
LRP-2; gp330  [Similar Products]
UniProt Entry Name
LRP2_HUMAN
NCBI Summary for LRP2
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
UniProt Comments for LRP2
LRP2: Acts together with cubilin to mediate HDL endocytosis. May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS); also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. Belongs to the LDLR family.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: Golgi apparatus; endocytic vesicle; lysosome; endoplasmic reticulum; brush border membrane; lysosomal membrane; apical plasma membrane; integral to membrane; plasma membrane; coated pit; receptor complex; endosome

Molecular Function: protein binding; calcium ion binding; SH3 domain binding

Biological Process: steroid metabolic process; phototransduction, visible light; cell proliferation; receptor-mediated endocytosis; forebrain development; protein amino acid glycosylation; endocytosis; lipid metabolic process; retinoid metabolic process; vitamin D metabolic process

Disease: Donnai-barrow Syndrome
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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