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anti-PRG4 antibody :: Goat Lubricin/PRG4 Polyclonal Antibody

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Catalog # MBS422087
Unit / Price
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  0.1 mg  /  $225 +1 FREE 8GB USB
anti-PRG4 antibody
Product Name

Lubricin/PRG4, Polyclonal Antibody

Full Product Name

Goat anti-Lubricin/PRG4 Antibody

Product Synonym Names
PRG4; proteoglycan 4; CACP; FLJ32635; HAPO; JCAP; MSF; SZP; bG174L6.2; Jacobs camptodactyly-arthropathy-pericarditis syndrome; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor); camptodactyly, arthropathy, coxa vara,; PRG4 antibody; proteoglycan 4 antibody; CACP antibody; FLJ32635 antibody; HAPO antibody; JCAP antibody; MSF antibody; SZP antibody; bG174L6.2 antibody; Jacobs camptodactyly-arthropathy-pericarditis syndrome antibody; articular superficial zone protein antibody; bG174L6.2 (MSF: megakaryocyte stimulating factor) antibody; camptodactyly; arthropathy; coxa vara; pericarditis syndrome antibody; lubricin antibody; megakaryocyte stimulating factor antibody; proteoglycan 4; (megakaryocyte stimulating factor; articular superficial zone protein; camptodactyly; arthropathy; coxa vara; pericarditis syndrome) antibody; Lubricin; Lubricin / PRG4
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
DYESFCAEVH NP
OMIM
208250
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence DYESFCAEVHNP, from the internal region of the protein sequence according to NP_005798.2.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-PRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PRG4 antibody
Peptide ELISA (EIA)
Application Notes for anti-PRG4 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Preliminary experiments in Human Bone Marrow lysates gave no specific signal but low background (at antibody concentration up to 0.3ug/ml).
NCBI/Uniprot data below describe general gene information for PRG4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
146,468 Da
NCBI Official Full Name
proteoglycan 4 isoform A
NCBI Official Synonym Full Names
proteoglycan 4
NCBI Official Symbol
NCBI Official Synonym Symbols
MSF; SZP; CACP; HAPO; JCAP
  [Similar Products]
NCBI Protein Information
proteoglycan 4
UniProt Protein Name
Proteoglycan 4
UniProt Synonym Protein Names
Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MSF; SZP  [Similar Products]
UniProt Entry Name
PRG4_HUMAN
NCBI Summary for PRG4
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for PRG4
PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q25-q31

Cellular Component: extracellular region

Molecular Function: polysaccharide binding; scavenger receptor activity

Biological Process: cell proliferation; immune response; receptor-mediated endocytosis

Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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