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anti-LUM antibody :: Rabbit anti-Human Lumican (LUM) Polyclonal Antibody

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Catalog # MBS2005925 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $170 +1 FREE 8GB USB
  0.1 mg  /  $220 +1 FREE 8GB USB
  0.2 mg  /  $320 +1 FREE 8GB USB
  1 mg  /  $760 +1 FREE 8GB USB
Product Name

Lumican (LUM), Polyclonal Antibody

Popular Item
Also Known As

Polyclonal Antibody to Lumican (LUM)

Product Gene Name
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
Biotin Conjugated Antibody: Lumican (LUM) (MBS2005682)
Matching Pairs
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
APC-CY7 Conjugated Antibody: Lumican (LUM) (MBS2055907)
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
PE Conjugated Antibody: Lumican (LUM) (MBS2055909)
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
APC Conjugated Antibody: Lumican (LUM) (MBS2055911)
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
Cy3 Conjugated Antibody: Lumican (LUM) (MBS2055913)
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
FITC Conjugated Antibody: Lumican (LUM) (MBS2055915)
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
HRP Conjugated Antibody: Lumican (LUM) (MBS2055917)
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
Matching Pairs
Unconjugated Antibody: Lumican (LUM) (MBS2005925)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
338
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-QY YDYDIPLFMY GQISPNCAPE CNCPHSYPTA MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLlLDHN LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLTNNKIS KLGSFDGLVN LTFIYLQHNQ LKEDAVSASL KGLKSLEYLD LSFNQMSKLP AGLPTSLLTL YLDNNKISNI PDEYFKRFTG LQYLRLSHNE LADSGVPGNS FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNELEKFD VKSFCKILGP LSYSKIKHLR LDGNPLTQSS LPPDMYECLR V,Il,NEITV N
OMIM
U18728 mRNA
3D Structure
ModBase 3D Structure for P51884
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against LUM. It has been selected for its ability to recognize LUM in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml
UOM: 100ug (lot specific)
Immunogen
Recombinant LUM (Gln19~Asn338) expressed in E.coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2055911
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-LUM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forLUMpurchase
As the name suggests, Lumican - LUM - is a constituent keratan sulfate proteoglycan family gene matrix protein with transparent properties required in human cornea and is also a known MMP proteins inhibitor. IHC, ELISA or western blot analysis to study these important roles require specific marker antibodies; an anti lumican antibody. An affinity purified and carefully selected rabbit anti lumican polyclonal custom antibody has been under development using peptide antibody production techniques and is available for research protocols to look at cell lysates or tissue localizations. This product, lum antibody and similar protein family antibodies, are easily detected by common secondary antibodies, such as goat anti rabbit, with Alexa 174 fluor or AMP conjugations. Further, no cross reactivity is noted for mouse or rat only human LUM. IHC WB datasheet describing additional services for custom antibody production or suggestions for loading control for WB make complete polyclonal antibody kits.
Applications Tested/Suitable for anti-LUM antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-LUM antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-LUM antibody
Western Blot: Sample: Human Lung lysate; Primary Ab: 1ug/ml Rabbit Anti-Human LUM Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-LUM antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-LUM antibody
Western Blot: Sample: Recombinant protein.
anti-LUM antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-LUM antibody
DAB staining on IHC-P. Samples: Human Tissue)
anti-LUM antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LUM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,429 Da
NCBI Official Full Name
lumican
NCBI Official Synonym Full Names
lumican
NCBI Official Symbol
NCBI Official Synonym Symbols
LDC; SLRR2D
  [Similar Products]
NCBI Protein Information
lumican
UniProt Protein Name
Lumican
UniProt Synonym Protein Names
Keratan sulfate proteoglycan lumican; KSPG lumican
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
LDC; SLRR2D; KSPG lumican  [Similar Products]
NCBI Summary for LUM
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
UniProt Comments for LUM
LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; extracellular region; extracellular space; fibrillar collagen trimer; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix

Molecular Function: collagen binding; extracellular matrix structural constituent; protein binding

Biological Process: axonogenesis; cartilage development; collagen fibril organization; extracellular matrix organization; keratan sulfate biosynthetic process; keratan sulfate catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta1 production; response to organic cyclic compound; visual perception
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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