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anti-LTbR antibody :: Rabbit anti-Human Lymphotoxin Beta Receptor (LTbR) Polyclonal Antibody

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Catalog # MBS2005935 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $165 +1 FREE 8GB USB
  0.1 mg  /  $210 +1 FREE 8GB USB
  0.2 mg  /  $310 +1 FREE 8GB USB
  1 mg  /  $725 +1 FREE 8GB USB
Product Name

Lymphotoxin Beta Receptor (LTbR), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to Lymphotoxin Beta Receptor (LTbR)

Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S-TYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLE
OMIM
L04270 mRNA
3D Structure
ModBase 3D Structure for P36941
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against LTbR. It has been selected for its ability to recognize LTbR in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml (lot specific)
Immunogen
Recombinant LTbR (Thr66~Glu215) expressed in E.coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2042906
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-LTbR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-LTbR antibody
Applications Tested/Suitable for anti-LTbR antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-LTbR antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-LTbR antibody
Western Blot: Sample: Human U-87MG Cells.
anti-LTbR antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-LTbR antibody
Western Blot: Sample: Recombinant LTbR, Human.
anti-LTbR antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-LTbR antibody
DAB staining on IHC-P; Samples: Human Prostate Gland Tissue.
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LTbR antibody
DAB staining on IHC-P; Samples: Human Liver Tissue
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LTbR antibody
DAB staining on IHC-P; Samples: Human Rectum Cancer Tissue
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LTbR antibody
DAB staining on IHC-P; Samples: Human Breast Cancer Tissue
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
Knockout Validation of anti-LTbR antibody
Knockout Validation: Lane 1: Wild-type U87MG cell lysate; Lane 2: LTbR knockout U87MG cell lysate; Predicted MW: 45,47kDa Observed MW: 47kDa Primary Ab: 3ug/ml Rabbit Anti-Human LTbR Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
anti-LTbR antibody Knockout Validation image
NCBI/Uniprot data below describe general gene information for LTbR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,810 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 3 isoform 2
NCBI Official Synonym Full Names
lymphotoxin beta receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 3
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 3
UniProt Synonym Protein Names
Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
UniProt Gene Name
UniProt Synonym Gene Names
D12S370; TNFCR; TNFR3; TNFRSF3; TNF-RIII; TNFR-III  [Similar Products]
NCBI Summary for LTbR
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
UniProt Comments for LTbR
LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: identical protein binding; protein binding; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding

Biological Process: apoptosis; immune response; inflammatory response; multicellular organism development; myeloid dendritic cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway; viral process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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