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anti-OPN4 antibody :: Rabbit anti-Human Melanopsin Polyclonal Antibody

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Catalog # MBS2535914
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Melanopsin (OPN4), Polyclonal Antibody

Popular Item
Full Product Name

Melanopsin Polyclonal Antibody

Product Synonym Names
OPN4; MOP; Melanopsin; Opsin-4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
606665
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the C-terminal region of human Melanopsin.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-OPN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-OPN4 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-OPN4 antibody
WB: 1:500-1:2000, IF: 1:50-1:100, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-OPN4 antibody
Western Blot analysis of COLO205 cells with Melanopsin Polyclonal Antibody.
anti-OPN4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for OPN4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 53
Observed MW: 55[Similar Products]
NCBI Official Full Name
melanopsin isoform 2
NCBI Official Synonym Full Names
opsin 4
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
melanopsin
UniProt Protein Name
Melanopsin
UniProt Synonym Protein Names
Opsin-4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
OPN4_HUMAN
NCBI Summary for OPN4
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for OPN4
melanopsin: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q22

Cellular Component: integral to membrane; plasma membrane

Molecular Function: 11-cis retinal binding; G-protein coupled photoreceptor activity

Biological Process: phototransduction; protein-chromophore linkage; regulation of circadian rhythm; rhodopsin mediated signaling; rhythmic process; visual perception
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-OPN4 antibody
Organs/Tissues associated with anti-OPN4 antibody
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