• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-MAOA antibody :: Goat Monoamine Oxidase A Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS421298
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $300 +1 FREE 8GB USB
Product Name

Monoamine Oxidase A (MAOA), Polyclonal Antibody

Full Product Name

Goat anti-Monoamine Oxidase A Antibody

Product Synonym Names
MAOA; monoamine oxidase A; HGNC: 6833; RP1-201D17__B.2; monoamine oxidase A antibody; HGNC: 6833 antibody; MAOA antibody; RP1-201D17__B.2 antibody; Monoamine Oxidase A; Monoamine Oxidase A
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
DAPWEAQHAD KWDK
OMIM
300615
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-DAPWEAQHADKWDK, from the internal region of the protein sequence according to NP_000231.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-MAOA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MAOA antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-MAOA antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 70kDa band observed in Human Heart lysates o(calculated MW of 60. 0kDa according to NP_000231.1). In transfected HEK293 transiently expressing MAOA a band of approx. 60 kDa is observed. This band is not observed in the non-transfected HEK293. The user is warned for non-specific background in Western blot. Recommended concentration: 0.1-0.3ug/ml.

Western Blot (WB) of anti-MAOA antibody
(0.3ug/ml) staining of human heart lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
anti-MAOA antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-MAOA antibody
HEK293 overexpressing MAOA (RC207276) and probed (mock transfection in first lane), tested by Origene.
anti-MAOA antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for MAOA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,848 Da
NCBI Official Full Name
amine oxidase
NCBI Official Synonym Full Names
monoamine oxidase A
NCBI Official Symbol
NCBI Official Synonym Symbols
MAO-A
  [Similar Products]
NCBI Protein Information
amine oxidase [flavin-containing] A
UniProt Protein Name
Amine oxidase [flavin-containing] A
UniProt Synonym Protein Names
Monoamine oxidase type A; MAO-A
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MAO-A  [Similar Products]
UniProt Entry Name
AOFA_HUMAN
NCBI Summary for MAOA
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Comments for MAOA
MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.

Protein type: EC 1.4.3.4; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - arginine and proline; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: integral to membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: amine oxidase activity; FAD binding; serotonin binding

Biological Process: biogenic amine metabolic process; dopamine catabolic process; neurotransmitter catabolic process; neurotransmitter metabolic process; phenylethylamine metabolic process; serotonin metabolic process

Disease: Brunner Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000