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anti-MSTN antibody :: Rabbit anti-Human MSTN / GDF8 / Myostatin Polyclonal Antibody

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Catalog # MBS240197
Unit / Price DISCONTINUED
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Immunohistochemistry (IHC)
Product Name

MSTN / GDF8 / Myostatin, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human MSTN / GDF8 / Myostatin

Product Synonym Names
Anti-MSTN / GDF8 / Myostatin Antibody IHC-plus; MSTN; GDF8; MSLHP; Myostatin; GDF-8; Human MSTN; GDF8; Myostatin
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 614160
3D Structure
ModBase 3D Structure for O14793
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Protein G Purified
Form/Format
PBS, 0.09% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Amino acids 24 - 39 [NENSEQKENVEKEGLC] of the human myostatin.
Immunogen Type
Synthetic peptide
Immunogen
MSTN / GDF8 / Myostatin antibody was raised against amino acids 24 - 39 [NENSEQKENVEKEGLC] of the human myostatin.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of anti-MSTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MSTN antibody
Myostatin (MSTN) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Product Categories/Family for anti-MSTN antibody
Applications Tested/Suitable for anti-MSTN antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-MSTN antibody
ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...

Immunohistochemistry (IHC) of anti-MSTN antibody
Anti-MSTN / Myostatin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MSTN antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MSTN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,750 Da
NCBI Official Full Name
growth/differentiation factor 8
NCBI Official Synonym Full Names
myostatin
NCBI Official Symbol
NCBI Official Synonym Symbols
GDF8; MSLHP
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NCBI Protein Information
growth/differentiation factor 8; GDF-8; growth differentiation factor 8
UniProt Protein Name
Growth/differentiation factor 8
UniProt Synonym Protein Names
Myostatin
UniProt Gene Name
UniProt Synonym Gene Names
GDF8; GDF-8  [Similar Products]
UniProt Entry Name
GDF8_HUMAN
NCBI Summary for MSTN
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]
UniProt Comments for MSTN
MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: heparin binding; identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: response to gravity; response to muscle activity; muscle development; positive regulation of transcription, DNA-dependent; skeletal muscle regeneration; response to testosterone stimulus; regulation of apoptosis; ovulation cycle process; skeletal muscle atrophy; negative regulation of muscle hypertrophy; response to ethanol; response to heat; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; negative regulation of skeletal muscle growth; response to electrical stimulus; cell development

Disease: Muscle Hypertrophy
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-MSTN antibody
 Products by Pathway  Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
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