NP_002440.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,897 Da
NCBI Official Full Name
homeobox protein MSX-2
NCBI Official Synonym Full Names
msh homeobox 2
NCBI Official Synonym Symbols
FPP; MSH; PFM; CRS2; HOX8; PFM1 [Similar Products]
NCBI Protein Information
homeobox protein MSX-2
UniProt Protein Name
Homeobox protein MSX-2
UniProt Synonym Protein Names
Homeobox protein Hox-8
UniProt Synonym Gene Names
NCBI Summary for MSX2
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX2
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
Research Articles on MSX2
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Products associated with anti-MSX2 antibody
Pathways associated with anti-MSX2 antibody
Diseases associated with anti-MSX2 antibody
Organs/Tissues associated with anti-MSX2 antibody
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