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anti-MVP antibody :: Rabbit anti-Human MVP / LRP Polyclonal Antibody

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Catalog # MBS241036
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

MVP / LRP, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit Polyclonal to Human MVP / LRP

Product Synonym Names
Anti-MVP / LRP Antibody (aa878-893) IHC-plus; MVP; Major vault protein; VAULT1; LRP; Human MVP; LRP
Product Gene Name
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605088
3D Structure
ModBase 3D Structure for Q14764
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Amino acids 878-893 of human MVP
Purity/Purification
Protein G Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human MVP.
Immunogen Type
Synthetic peptide
Immunogen
MVP / LRP antibody was raised against synthetic peptide from human MVP.
Antigen Modification
aa878-893
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of anti-MVP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MVP antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-MVP antibody
ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-MVP antibody
Anti-MVP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MVP antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MVP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
99,327 Da
NCBI Official Full Name
major vault protein isoform 1
NCBI Official Synonym Full Names
major vault protein
NCBI Official Symbol
NCBI Official Synonym Symbols
LRP; VAULT1
  [Similar Products]
NCBI Protein Information
major vault protein; lung resistance-related protein
UniProt Protein Name
Major vault protein
UniProt Synonym Protein Names
Lung resistance-related protein
UniProt Gene Name
UniProt Synonym Gene Names
LRP; MVP  [Similar Products]
UniProt Entry Name
MVP_HUMAN
NCBI Summary for MVP
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for MVP
MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; ribonucleoprotein complex; nucleus

Molecular Function: protein binding; protein phosphatase binding; protein kinase binding

Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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