NP_000250.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
218,608 Da
NCBI Official Full Name
unconventional myosin-Va isoform 1
NCBI Official Synonym Full Names
myosin VA
NCBI Protein Information
unconventional myosin-Va
UniProt Protein Name
Unconventional myosin-Va
UniProt Synonym Protein Names
Dilute myosin heavy chain, non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin
UniProt Synonym Gene Names
UniProt Entry Name
MYO5A_HUMAN
NCBI Summary for MYO5A
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]
UniProt Comments for MYO5A
MYO5A: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation. May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Detected in melanocytes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q21
Cellular Component: Golgi apparatus; filopodium tip; neuron projection; endoplasmic reticulum; lysosome; early endosome; intermediate filament; actomyosin; actin filament; cytosol; ruffle; recycling endosome; photoreceptor outer segment; growth cone; membrane; cell soma; late endosome; cytoplasm; melanosome; peroxisome; myosin complex; vesicle
Molecular Function: microfilament motor activity; calmodulin binding; calcium ion binding; actin binding; ATP binding; Rab GTPase binding
Biological Process: myelination; exocytosis; ER localization; actin filament-based movement; long-chain fatty acid biosynthetic process; melanosome transport; locomotion during locomotory behavior; melanin biosynthetic process; vesicle-mediated transport; odontogenesis; synaptic transmission; vesicle transport along actin filament; cellular protein metabolic process; cellular response to insulin stimulus; visual perception; insulin secretion; transport; melanocyte differentiation; synapse organization and biogenesis; regulation of inositol-1,4,5-triphosphate receptor activity; post-Golgi vesicle-mediated transport; secretory granule localization
Disease: Griscelli Syndrome, Type 1
Research Articles on MYO5A
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Products associated with anti-MYO5A antibody
Pathways associated with anti-MYO5A antibody
Diseases associated with anti-MYO5A antibody
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