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anti-MYOC antibody :: Rabbit anti-Human Myocilin (MYOC) Polyclonal Antibody

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Catalog # MBS2001639 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $175 +1 FREE 8GB USB
  0.1 mg  /  $225 +1 FREE 8GB USB
  0.2 mg  /  $340 +1 FREE 8GB USB
  1 mg  /  $800 +1 FREE 8GB USB
Product Name

Myocilin (MYOC), Polyclonal Antibody

Also Known As

Polyclonal Antibody to Myocilin (MYOC)

Matching Pairs
Matching Pairs
Unconjugated Antibody: Myocilin (MYOC) (MBS2001639)
APC-CY7 Conjugated Antibody: Myocilin (MYOC) (MBS2080027)
Matching Pairs
Unconjugated Antibody: Myocilin (MYOC) (MBS2001639)
PE Conjugated Antibody: Myocilin (MYOC) (MBS2080028)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
260
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- ASRILKE SPSGYLRSGE GDTGCGELVW VGEPLTLRTA ETITGKYGVW MRDPKPTYPY TQETTWRIDT VGTDVRQVFE YDLISQFMQG YPSKVHILPR PLESTGAVVY SGSLYFQGAE SRTVIRYELN TETVKAEKEI PGAGYHGQFP YSWGGYTDID LAVDEAGLWV IYSTDEAKGA IVLSKLNPEN LELEQTWETN IRKQSVANAF IICGTLYTVS SYTSADATVN FAYDTGTGIS KTLTIPFKNR Y
OMIM
AF001620 mRNA
3D Structure
ModBase 3D Structure for Q99972
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against MYOC. It has been selected for its ability to recognize MYOC in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml (lot specific)
Immunogen
Recombinant MYOC (Ala224~Tyr471) expressed in E.coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2080029
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-MYOC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MYOC antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-MYOC antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-MYOC antibody
Western Blot: Sample: Lane1: Human Lung Tissue; Lane2: Human Heart Tissue.
anti-MYOC antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-MYOC antibody
Western Blot: Sample: Recombinant MYOC, Human.
anti-MYOC antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MYOC antibody
DAB staining on IHC-P. Samples: Human Tissue)
anti-MYOC antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MYOC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,972 Da
NCBI Official Full Name
myocilin
NCBI Official Synonym Full Names
myocilin
NCBI Official Symbol
NCBI Official Synonym Symbols
GPOA; JOAG; TIGR; GLC1A; JOAG1
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NCBI Protein Information
myocilin
UniProt Protein Name
Myocilin
UniProt Synonym Protein Names
Myocilin, N-terminal fragmentAlternative name(s):Myocilin 20 kDa N-terminal fragment
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for MYOC
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]
UniProt Comments for MYOC
MYOC: May participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Defects in MYOC are a cause of primary congenital glaucoma type 3A (GLC3A). An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. MYOC variations may contribute to GLC3A via digenic inheritance with CYP1B1 and/or another locus associated with the disease.

Protein type: Endoplasmic reticulum; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q24.3

Cellular Component: cilium; cytoplasmic vesicle; endoplasmic reticulum; extracellular matrix; extracellular space; Golgi apparatus; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial outer membrane; proteinaceous extracellular matrix; rough endoplasmic reticulum

Molecular Function: fibronectin binding; frizzled binding; metal ion binding; myosin light chain binding; protein binding; receptor tyrosine kinase binding

Biological Process: clustering of voltage-gated sodium channels; myelination in the peripheral nervous system; negative regulation of cell-matrix adhesion; negative regulation of Rho protein signal transduction; negative regulation of stress fiber formation; neuron projection development; osteoblast differentiation; positive regulation of cell migration; positive regulation of focal adhesion assembly; positive regulation of mitochondrial depolarization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling; positive regulation of stress fiber formation; regulation of MAPK cascade; skeletal muscle hypertrophy

Disease: Glaucoma 1, Open Angle, A
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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