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anti-NAGLU antibody :: Rabbit anti-Human N-Acetyl Alpha-D-Glucosaminidase Polyclonal Antibody

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Catalog # MBS2027566 (3 units are in stock [0.1 mg] for immediate shipment)
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $175 +1 FREE 8GB USB
  0.1 mg  /  $225 +1 FREE 8GB USB
  0.2 mg  /  $340 +1 FREE 8GB USB
  1 mg  /  $800 +1 FREE 8GB USB
Product Name

N-Acetyl Alpha-D-Glucosaminidase (NAGLU), Polyclonal Antibody

Popular Item
Also Known As

Polyclonal Antibody to N-Acetyl Alpha-D-Glucosaminidase (NAGLU)

Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U43572 Genomic DNA
3D Structure
ModBase 3D Structure for P54802
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a Rabbit polyclonal antibody raised against NAGLU. It has been selected for its ability to recognize NAGLU in immunohistochemical staining and western blotting.
Purity/Purification
Antigen-specific Affinity Chromatography
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
Concentration
200ug/ml (lot specific)
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant NAGLU (Val485~Trp743) expressed in E.coli
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2070317
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for two years.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of anti-NAGLU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NAGLU antibody
WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM
Application Notes for anti-NAGLU antibody
Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml

Optimal working dilutions must be determined by end user

Western Blot (WB) of anti-NAGLU antibody
Western Blot: Sample: Recombinant protein.
anti-NAGLU antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-NAGLU antibody
DAB staining on fromalin fixed paraffin-embedded kidney tissue)
anti-NAGLU antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-NAGLU antibody
DAB staining on IHC-P; Samples: Human Kidney Tissue)
anti-NAGLU antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for NAGLU. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
82,266 Da
NCBI Official Full Name
alpha-N-acetylglucosaminidase
NCBI Official Synonym Full Names
N-acetyl-alpha-glucosaminidase
NCBI Official Symbol
NAGLU  [Similar Products]
NCBI Official Synonym Symbols
NAG; CMT2V; MPS3B; UFHSD; MPS-IIIB
  [Similar Products]
NCBI Protein Information
alpha-N-acetylglucosaminidase
UniProt Protein Name
Alpha-N-acetylglucosaminidase
UniProt Synonym Protein Names
N-acetyl-alpha-glucosaminidase; NAG
UniProt Gene Name
NAGLU  [Similar Products]
UniProt Synonym Gene Names
UFHSD1; NAG  [Similar Products]
NCBI Summary for NAGLU
This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]
UniProt Comments for NAGLU
NAGLU: Involved in the degradation of heparan sulfate. Defects in NAGLU are the cause of mucopolysaccharidosis type 3B (MPS3B); also known as Sanfilippo syndrome B. MPS3B is a form of mucopolysaccharidosis type 3, an autosomal recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is characterized by severe central nervous system degeneration, but only mild somatic disease. Onset of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs in most patients between 6 and 10 years of age, and death occurs typically during the second or third decade of life.

Protein type: EC 3.2.1.50; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: extracellular exosome; lysosomal lumen; lysosome

Molecular Function: alpha-N-acetylglucosaminidase activity

Biological Process: cerebellar Purkinje cell layer development; glycosaminoglycan catabolic process; inner ear receptor cell development; locomotor rhythm; lysosome organization and biogenesis; middle ear morphogenesis; nervous system development; retinal rod cell development

Disease: Charcot-marie-tooth Disease, Axonal, Type 2v; Mucopolysaccharidosis, Type Iiib
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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