NP_005372.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,614 Da
NCBI Official Full Name
nucleolin
NCBI Official Synonym Full Names
nucleolin
NCBI Official Synonym Symbols
NCBI Protein Information
nucleolin
UniProt Protein Name
Nucleolin
UniProt Synonym Protein Names
Protein C23
UniProt Entry Name
NUCL_HUMAN
NCBI Summary for NCL
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
UniProt Comments for NCL
NCL: the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-RNA transcription and ribosome assembly.
Protein type: Helicase; RNA-binding; DNA-binding; Nuclear receptor co-regulator; Nucleolus
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cell cortex; cell surface; dense fibrillar component; fibrillar center; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function: calcium ion binding; histone binding; identical protein binding; laminin binding; nucleotide binding; protein binding; protein C-terminus binding; RNA binding; rRNA primary transcript binding; single-stranded DNA binding; telomeric DNA binding
Biological Process: angiogenesis; endocytosis; negative regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; spermatogenesis
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Products associated with anti-NCL antibody
Pathways associated with anti-NCL antibody
Diseases associated with anti-NCL antibody
Organs/Tissues associated with anti-NCL antibody
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