NP_001036189.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,359 Da
NCBI Official Full Name
nectin-2 isoform delta
NCBI Official Synonym Full Names
nectin cell adhesion molecule 2
NCBI Official Synonym Symbols
HVEB; PRR2; CD112; PVRL2; PVRR2 [Similar Products]
NCBI Protein Information
nectin-2
UniProt Protein Name
Nectin-2
UniProt Synonym Protein Names
Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2
UniProt Synonym Gene Names
NCBI Summary for NECTIN2
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for NECTIN2
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
Research Articles on NECTIN2
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Products associated with anti-NECTIN2 antibody
Pathways associated with anti-NECTIN2 antibody
Diseases associated with anti-NECTIN2 antibody
Organs/Tissues associated with anti-NECTIN2 antibody
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