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anti-NFE2L2 antibody :: Rabbit anti-Human NFE2L2 / NRF2 Polyclonal Antibody

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Catalog # MBS242657
Unit / Price
  0.25 mL  /  $530 +1 FREE 8GB USB
Product Name

NFE2L2 / NRF2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human NFE2L2 / NRF2

Product Synonym Names
Anti-NFE2L2 / NRF2 Antibody (aa569-588) IHC-plus; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; NRF2; Human NFE2L2; NRF2
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600492
3D Structure
ModBase 3D Structure for Q16236
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Immunoaffinity Purified
Form/Format
10mM PBS/1% BSA buffer pH 7.4 with 0.1% sodium azide.
Target Species
Human
Immunogen Description
Synthetic peptide corresponding to aa 569-588 of human Nrf2 protein.
Immunogen Type
Synthetic peptide
Immunogen
NFE2L2 / NRF2 antibody was raised against synthetic peptide corresponding to aa 569-588 of human Nrf2 protein.
Antigen Modification
aa569-588
Preparation and Storage
Store at 2 degree C to 8 degree C degrees. Do not freeze.
Other Notes
Small volumes of anti-NFE2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NFE2L2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-NFE2L2 antibody
IHC-P (1:200)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-NFE2L2 antibody
Anti-NRF2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-NFE2L2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-NFE2L2 antibody
Anti-NRF2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-NFE2L2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for NFE2L2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,356 Da
NCBI Official Full Name
nuclear factor erythroid 2-related factor 2 isoform 1
NCBI Official Synonym Full Names
nuclear factor, erythroid 2-like 2
NCBI Official Symbol
NFE2L2  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
nuclear factor erythroid 2-related factor 2; HEBP1; NFE2-related factor 2; NF-E2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid derived 2, like 2
UniProt Protein Name
Nuclear factor erythroid 2-related factor 2
UniProt Synonym Protein Names
HEBP1; Nuclear factor, erythroid derived 2, like 2
UniProt Gene Name
NFE2L2  [Similar Products]
UniProt Synonym Gene Names
NRF2; NF-E2-related factor 2; NFE2-related factor 2  [Similar Products]
UniProt Entry Name
NF2L2_HUMAN
NCBI Summary for NFE2L2
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for NFE2L2
NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; cytosol; nucleus; chromatin

Molecular Function: protein domain specific binding; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of blood coagulation; unfolded protein response; regulation of embryonic development; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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