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anti-NR3C1 antibody :: Rabbit anti-Human NR3C1 Polyclonal Antibody

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Catalog # MBS854804
Unit / Price
  0.1 mg  /  $330 +1 FREE 8GB USB
Testing Data
Product Name

NR3C1, Polyclonal Antibody

Also Known As

NR3C1 Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
742
OMIM
138040
3D Structure
ModBase 3D Structure for P04150
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified by peptide affinity column containing 2% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-NR3C1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR3C1 antibody
Rabbit polyclonal NR3C1 (1) antibody was raised against a peptide from near the C terminal residues of human NR3C1 protein.
Applications Tested/Suitable for anti-NR3C1 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-NR3C1 antibody
Peptide ELISA: 1:40,000-1:80,000
IHC: 1:50-200

Testing Data of anti-NR3C1 antibody
anti-NR3C1 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for NR3C1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,802 Da
NCBI Official Full Name
glucocorticoid receptor isoform beta
NCBI Official Synonym Full Names
nuclear receptor subfamily 3 group C member 1
NCBI Official Symbol
NR3C1  [Similar Products]
NCBI Official Synonym Symbols
GR; GCR; GRL; GCCR; GCRST
  [Similar Products]
NCBI Protein Information
glucocorticoid receptor
UniProt Protein Name
Glucocorticoid receptor
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group C member 1
Protein Family
UniProt Gene Name
NR3C1  [Similar Products]
UniProt Synonym Gene Names
GRL; GR  [Similar Products]
NCBI Summary for NR3C1
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
UniProt Comments for NR3C1
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth ().
Product References and Citations for anti-NR3C1 antibody
(1) Bhandare, R., Damera, G., Banerjee, A., et al. Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells.Am. J. Respir. Cell Mol. Biol. 42 (1), 9-15 (2010).

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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