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anti-NR5A2 antibody :: Rabbit anti-Human NR5A2 / LRH-1 Polyclonal Antibody

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Catalog # MBS241738
Unit / Price
  0.05 mL  /  $530 +1 FREE 8GB USB
Product Name

NR5A2 / LRH-1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human NR5A2 / LRH-1

Product Synonym Names
Anti-NR5A2 / LRH-1 Antibody (aa1-67) IHC-plus; NR5A2; B1F; B1F2; B1-binding factor; CPF; CYP7A promoter-binding factor; FTZ-F1beta; FTF; Liver receptor homolog 1; LRH1; LRH-1; HB1F; HB1F-2; Nuclear receptor phr-1; FTZ-F1; Liver receptor homolog-1; Nuclear receptor NR5A2; Human NR5A2; LRH-1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604453
3D Structure
ModBase 3D Structure for O00482
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Peptide corresponding to amino acids 1-67 of human CPF, member 2, variant 2
Purity/Purification
Immunoaffinity Purified
Form/Format
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
Target Species
Human
Immunogen Description
Synthetic peptide from human NR5A2.
Immunogen Type
Synthetic peptide
Immunogen
NR5A2 / LRH-1 antibody was raised against synthetic peptide from human NR5A2.
Antigen Modification
aa1-67
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-NR5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR5A2 antibody
Alpha1-fetoprotein transcription factor (Ftf), a NR5 fushi tarazu-like receptor, also is known as 'human B1-binding factor' (HB1F), 'CYP7A promoter-binding factor' (CPF), and 'liver receptor homolog 1' (LRH1). Ftf has been shown to affect the transcription of hepatic genes including alpha fetoprotein encoding gene (AFP), viral hepatitis B enhancer II, and 7-alpha-hydroxylase encoding gene (CYP7A1). Ftf has also been shown to affect hepatic cholesterol metabolism and bile acid synthesis.
Applications Tested/Suitable for anti-NR5A2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-NR5A2 antibody
IHC-P (1:50), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-NR5A2 antibody
Anti-NR5A2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-NR5A2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-NR5A2 antibody
Hela cell nuclear extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-CPF antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
anti-NR5A2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NR5A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,657 Da
NCBI Official Full Name
nuclear receptor subfamily 5 group A member 2 isoform 2
NCBI Official Synonym Full Names
nuclear receptor subfamily 5, group A, member 2
NCBI Official Symbol
NR5A2  [Similar Products]
NCBI Official Synonym Symbols
B1F; CPF; FTF; B1F2; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta
  [Similar Products]
NCBI Protein Information
nuclear receptor subfamily 5 group A member 2; nuclear receptor NR5A2; liver receptor homolog 1; liver receptor homolog-1; CYP7A promoter-binding factor; hepatocytic transcription factor hB1F-3; alpha-1-fetoprotein transcription factor; liver nuclear receptor homolog-1 variant 2; fetoprotein-alpha 1 (AFP) transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus
UniProt Protein Name
Nuclear receptor subfamily 5 group A member 2
UniProt Synonym Protein Names
Alpha-1-fetoprotein transcription factor; B1-binding factor; hB1F; CYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1; LRH-1
UniProt Gene Name
NR5A2  [Similar Products]
UniProt Synonym Gene Names
B1F; CPF; FTF; hB1F; LRH-1  [Similar Products]
UniProt Entry Name
NR5A2_HUMAN
UniProt Comments for NR5A2
NR5A2: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Belongs to the nuclear hormone receptor family. NR5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; phospholipid binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; positive regulation of viral genome replication; intracellular receptor-mediated signaling pathway; bile acid metabolic process; positive regulation of transcription, DNA-dependent; endocrine pancreas development; regulation of cell proliferation; embryonic development; cholesterol homeostasis; regulation of transcription, DNA-dependent; homeostatic process; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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