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anti-NT-proBNP antibody :: Rabbit anti-Human NT-proBNP Polyclonal Antibody

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Catalog # MBS715412
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

NT-proBNP, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human NT-proBNP polyclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS715412 Technical Datasheet
OMIM
600295
3D Structure
ModBase 3D Structure for P16860
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
PBS
Conjugate
Non-conjugated
Immunogen
Recombinant human NT-proBNP protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18814 / sc-18813 / sc-20159
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-NT-proBNP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NT-proBNP antibody
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Applications Tested/Suitable for anti-NT-proBNP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-NT-proBNP antibody
Western blot
All lanes: NT-proBNP antibody at 2ug/ml+Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 15kDa
Observed band size: 15kDa

anti-NT-proBNP antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-NT-proBNP antibody
Immunohistochemistry of paraffin-embedded human brain tissue using MBS715412 at dilution 1:100
anti-NT-proBNP antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-NT-proBNP antibody
Immunohistochemistry of paraffin-embedded human heart tissue using MBS715412 at dilution 1:100
anti-NT-proBNP antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for NT-proBNP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,726 Da
NCBI Official Full Name
natriuretic peptides B preproprotein
NCBI Official Synonym Full Names
natriuretic peptide B
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
natriuretic peptides B
UniProt Protein Name
Natriuretic peptides B
UniProt Synonym Protein Names
Gamma-brain natriuretic peptide
UniProt Gene Name
UniProt Synonym Gene Names
BNP(1-32); BNP-32  [Similar Products]
UniProt Entry Name
ANFB_HUMAN
NCBI Summary for NT-proBNP
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
UniProt Comments for NT-proBNP
NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Secreted; Hormone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: extracellular region; extracellular space; protein complex

Molecular Function: diuretic hormone activity; hormone activity; protein binding; receptor binding

Biological Process: body fluid secretion; cell surface receptor linked signal transduction; cGMP biosynthetic process; negative regulation of angiogenesis; negative regulation of cell growth; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; regulation of vasodilation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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