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anti-OAS3 antibody :: Rabbit anti-Human OAS3 Polyclonal Antibody

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Catalog # MBS9130446 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Western Blot (WB)
Product Name

OAS3, Polyclonal Antibody

Popular Item
Full Product Name

OAS3 Polyclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603351
3D Structure
ModBase 3D Structure for Q9Y6K5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human OAS3
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-OAS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-OAS3 antibody
Applications Tested/Suitable for anti-OAS3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-OAS3 antibody
WB: 1:200 - 1:2000, IHC: 1:20 - 1:200, IF: 1:20 - 1:100

Western Blot (WB) of anti-OAS3 antibody
Western blot analysis of extracts of various cell lines, using OAS3 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
anti-OAS3 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for OAS3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 121kDa
NCBI Official Full Name
2'-5'-oligoadenylate synthase 3
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase 3
NCBI Official Symbol
NCBI Official Synonym Symbols
p100; p100OAS
  [Similar Products]
NCBI Protein Information
2'-5'-oligoadenylate synthase 3
UniProt Protein Name
2'-5'-oligoadenylate synthase 3
UniProt Synonym Protein Names
p100 OAS; p100OAS
UniProt Gene Name
UniProt Synonym Gene Names
(2-5')oligo(A) synthase 3; 2-5A synthase 3; p100OAS  [Similar Products]
UniProt Entry Name
OAS3_HUMAN
NCBI Summary for OAS3
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
UniProt Comments for OAS3
OAS3: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). Belongs to the 2-5A synthase family.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: cytoplasm; cytosol; extracellular space; intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function: 2'-5'-oligoadenylate synthetase activity; ATP binding; double-stranded RNA binding; metal ion binding; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; negative regulation of viral genome replication; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to virus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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