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anti-Oasl2 antibody :: Rabbit anti-Human OASL Polyclonal Antibody

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Catalog # MBS630945
Unit / Price
  0.2 mL  /  $610 +1 FREE 8GB USB
anti-Oasl2 antibody
Product Name

OASL (Oasl2), Polyclonal Antibody

Full Product Name

OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14)

Product Synonym Names
Anti -OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000071.6 (114896934..114912245). Location: 5 F; 5
3D Structure
ModBase 3D Structure for Q9Z2F2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Recognizes human OASL.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the C-terminal region of human OASL (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-Oasl2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Oasl2 antibody
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514aa human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
Applications Tested/Suitable for anti-Oasl2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Oasl2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
NCBI/Uniprot data below describe general gene information for Oasl2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,767 Da[Similar Products]
NCBI Official Full Name
Oasl2 protein
NCBI Official Synonym Full Names
2'-5' oligoadenylate synthetase-like 2
NCBI Official Symbol
Oasl2  [Similar Products]
NCBI Official Synonym Symbols
Oasl; M1204; Mmu-OASL
  [Similar Products]
NCBI Protein Information
2'-5'-oligoadenylate synthase-like protein 2; p54OASL; p54 OASL; 54 kDa 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthetase-like protein 2
UniProt Protein Name
2'-5'-oligoadenylate synthase-like protein 2
UniProt Synonym Protein Names
54 kDa 2'-5'-oligoadenylate synthase-like protein; p54 OASL; M1204
UniProt Gene Name
Oasl2  [Similar Products]
UniProt Synonym Gene Names
p54 OASL  [Similar Products]
UniProt Entry Name
OASL2_MOUSE
UniProt Comments for Oasl2
Oasl2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family.

Protein type: EC 2.7.7.84

Molecular Function: transferase activity; RNA binding; metal ion binding; double-stranded RNA binding; nucleotide binding; ATP binding; 2'-5'-oligoadenylate synthetase activity; nucleotidyltransferase activity

Biological Process: immune system process; response to virus; innate immune response; immune response; purine nucleotide biosynthetic process; defense response to virus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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