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anti-SLCO1A2 antibody :: Rabbit anti-Human OATP Polyclonal Antibody

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Catalog # MBS617855
Unit / Price
  0.1 mL  /  $720 +1 FREE 8GB USB
anti-SLCO1A2 antibody
Product Name

OATP (SLCO1A2), Polyclonal Antibody

Full Product Name

OATP (Organic anion transporting polypeptide)

Product Synonym Names
Anti -OATP (Organic anion transporting polypeptide)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (21417534..21548371, complement). Location: 12p12
OMIM
602883
3D Structure
ModBase 3D Structure for P46721
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Recognizes human OATP (Organic anion transporting polypeptide). No significant sequence homology is detected with other oatp1-3 or human LST-1.
Purity/Purification
Serum
Serum.
Form/Format
Supplied as a liquid in 0.05% sodium azide, 40% glycerol.
Immunogen
15-aa peptide near the C-terminus, extracellular domain of Human OATP (KLH) (gene accession # P46721).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-SLCO1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLCO1A2 antibody
Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). Rat Oatp, now called oatp1, encodes a protein of 670 aa. Oatp1 was localized at the apical portions of the S3 segment of the proximal tubule, and at the apical surface of the choroid plexus of rat brain. It is also found in liver, lung, skeletal muscle, and colon. It mediates Na+-independent uptake of wide range of amphipathic
Applications Tested/Suitable for anti-SLCO1A2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SLCO1A2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000 A band of 95-110kD has been detected in brush border membrane (2).
ELISA: 1:10,000-50,000 Control peptide can be used to coat ELISA plates at 1ug/ml.
NCBI/Uniprot data below describe general gene information for SLCO1A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,145 Da[Similar Products]
NCBI Official Full Name
organic anion transporting polypeptide
NCBI Official Synonym Full Names
solute carrier organic anion transporter family, member 1A2
NCBI Official Symbol
SLCO1A2  [Similar Products]
NCBI Official Synonym Symbols
OATP; OATP-A; OATP1A2; SLC21A3
  [Similar Products]
NCBI Protein Information
solute carrier organic anion transporter family member 1A2; OATP-1; OTTHUMP00000209604; OTTHUMP00000209605; solute carrier family 21 member 3; organic anion transporting polypeptide A; organic anion-transporting polypeptide 1; sodium-independent organic anion transporter; solute carrier family 21 (organic anion transporter), member 3
UniProt Protein Name
Solute carrier organic anion transporter family member 1A2
UniProt Synonym Protein Names
OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3
UniProt Gene Name
SLCO1A2  [Similar Products]
UniProt Synonym Gene Names
OATP; OATP1; OATP1A2; SLC21A3  [Similar Products]
UniProt Entry Name
SO1A2_HUMAN
NCBI Summary for SLCO1A2
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
UniProt Comments for SLCO1A2
SLCO1A2: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: plasma membrane; integral to membrane

Molecular Function: organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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