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anti-PAICS antibody :: Rabbit anti-Human PAICS Polyclonal Antibody

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Catalog # MBS7045680
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

PAICS, Polyclonal Antibody

Popular Item
Full Product Name

PAICS Antibody

Product Synonym Names
Multifunctional protein ADE2; Phosphoribosylaminoimidazole-succinocarboxamide synthase; SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC; PAICS; ADE2; AIRC; PAIS
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
172439
3D Structure
ModBase 3D Structure for P22234
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Multifunctional protein ADE2 protein (C-250AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16150
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PAICS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAICS antibody
cytosol, extracellular exosome, membrane, identical protein binding, phosphoribosylaminoimidazole carboxylase activity, phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, 'de novo' IMP biosynthetic process, adenine biosynthetic process, purine nucleobase biosynthetic process, purine ribonucleoside monophosphate biosynthetic process
Applications Tested/Suitable for anti-PAICS antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-PAICS antibody
Western blot
All lanes:  PAICSantibody at 3.98ug/ml
Lane 1 : Hela whole cell lysate
Lane 2 : Raji whole cell lysate
Lane 3 : 293T whole cell lysate
Lane 4 : NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa

anti-PAICS antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PAICS antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7045680 at dilution 1:100
anti-PAICS antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PAICS antibody
Immunohistochemistry of paraffin-embedded human testis tissue using MBS7045680 at dilution 1:100
anti-PAICS antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PAICS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,958 Da
NCBI Official Full Name
multifunctional protein ADE2 isoform 2
NCBI Official Synonym Full Names
phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
NCBI Official Symbol
PAICS  [Similar Products]
NCBI Official Synonym Symbols
ADE2; AIRC; PAIS; ADE2H1
  [Similar Products]
NCBI Protein Information
multifunctional protein ADE2
UniProt Protein Name
Multifunctional protein ADE2
UniProt Synonym Protein Names
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)Alternative name(s):SAICAR synthetase
Protein Family
UniProt Gene Name
PAICS  [Similar Products]
UniProt Synonym Gene Names
ADE2; AIRC; PAIS; AIRC  [Similar Products]
UniProt Entry Name
PUR6_HUMAN
NCBI Summary for PAICS
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PAICS
PAICS: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 4.1.1.21; EC 6.3.2.6; Nucleotide Metabolism - purine; Lyase

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: cytosol; membrane

Molecular Function: identical protein binding; phosphoribosylaminoimidazole carboxylase activity; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; protein binding

Biological Process: 'de novo' IMP biosynthetic process; adenine biosynthetic process; purine base biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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