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anti-PAPSS1 antibody :: Rabbit anti-Human PAPSS1 Polyclonal Antibody

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Catalog # MBS9201747
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

PAPSS1, Polyclonal Antibody

Full Product Name

PAPSS1 Antibody (C-term A607)

Product Synonym Names
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPS synthase 1; PAPSS 1; Sulfurylase kinase 1; SK 1; SK1; Sulfate adenylyltransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase; PAPSS1; ATPSK1; PAPSS
Antibody/Peptide Pairs
PAPSS1 peptide (MBS9224725) is used for blocking the activity of PAPSS1 antibody (MBS9201747)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
3D Structure
ModBase 3D Structure for O43252
Rabbit Ig
Species Reactivity
This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.
Purified Rabbit Polyclonal Antibody (Pab)
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Vial Concentration: 2 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PAPSS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAPSS1 antibody
Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98% identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.
Product Categories/Family for anti-PAPSS1 antibody
Applications Tested/Suitable for anti-PAPSS1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PAPSS1 antibody

Western Blot (WB) of anti-PAPSS1 antibody
Western blot analysis of anti-PAPSS1 Antibody (C-term A607) in A2058 cell line lysates (35ug/lane). PAPSS1(arrow) was detected using the purified Pab.
anti-PAPSS1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for PAPSS1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Official Symbol
PAPSS1  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Synonym Protein Names
Sulfurylase kinase 1; SK 1; SK1
UniProt Gene Name
PAPSS1  [Similar Products]
UniProt Synonym Gene Names
ATPSK1; PAPSS; PAPS synthase 1; PAPSS 1; SK 1; SK1; SAT  [Similar Products]
UniProt Entry Name
NCBI Summary for PAPSS1
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
UniProt Comments for PAPSS1
PAPSS1: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Protein type: Nucleotide Metabolism - purine; EC; EC; Kinase, other; Energy Metabolism - sulfur; Other Amino Acids Metabolism - selenoamino acid

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: cytosol

Molecular Function: adenylylsulfate kinase activity; ATP binding; sulfate adenylyltransferase (ATP) activity; nucleotidyltransferase activity

Biological Process: sulfate assimilation; glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; pathogenesis; skeletal development; phosphorylation; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
Product References and Citations for anti-PAPSS1 antibody
Biochemistry 43 (14), 4356-4365 (2004)
IUBMB Life 55 (1), 1-11 (2003)
Biochem. J. 365 (PT 2), 497-504 (2002)
Biochem. Biophys. Res. Commun. 268 (2), 437-444 (2000)
FASEB J. 14 (2), 345-354 (2000)

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