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anti-PAPSS2 antibody :: Rabbit anti-Human PAPSS2 Polyclonal Antibody

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Catalog # MBS9214669
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

PAPSS2, Polyclonal Antibody

Full Product Name

PAPSS2 Antibody (C-term)

Product Synonym Names
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; PAPS synthase 2; PAPSS 2; Sulfurylase kinase 2; SK 2; SK2; Sulfate adenylyltransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase; PAPSS2; ATPSK2
Antibody/Peptide Pairs
PAPSS2 peptide (MBS9227530) is used for blocking the activity of PAPSS2 antibody (MBS9214669)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
544-574
OMIM
603005
3D Structure
ModBase 3D Structure for O95340
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This PAPSS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 544-574 amino acids from the C-terminal region of human PAPSS2.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PAPSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAPSS2 antibody
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.
Product Categories/Family for anti-PAPSS2 antibody
Applications Tested/Suitable for anti-PAPSS2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-PAPSS2 antibody
WB~~1:1000

Western Blot (WB) of anti-PAPSS2 antibody
The anti-PAPSS2 Pab is used in Western blot to detect PAPSS2 in Jurkat cell lysate.
anti-PAPSS2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PAPSS2 antibody
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
anti-PAPSS2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PAPSS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69501
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 2
NCBI Official Symbol
PAPSS2  [Similar Products]
NCBI Official Synonym Symbols
SK2; BCYM4; ATPSK2
  [Similar Products]
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
UniProt Synonym Protein Names
Sulfurylase kinase 2; SK 2; SK2
UniProt Gene Name
PAPSS2  [Similar Products]
UniProt Synonym Gene Names
ATPSK2; PAPS synthase 2; PAPSS 2; SK 2; SK2; SAT  [Similar Products]
UniProt Entry Name
PAPS2_HUMAN
NCBI Summary for PAPSS2
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PAPSS2
PAPSS2: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important role in skeletogenesis during postnatal growth. Defects in PAPSS2 are the cause of spondyloepimetaphyseal dysplasia Pakistani type (SEMD-PA). A bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Clinical features include short stature evidenced at birth, short and bowed lower limbs, mild brachydactyly, kyphoscoliosis, abnormal gait, enlarged knee joints. Some patients may manifest premature pubarche and hyperandrogenism associated with skeletal dysplasia and short stature. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Energy Metabolism - sulfur; Transferase; EC 2.7.7.4; Other Amino Acids Metabolism - selenoamino acid; EC 2.7.1.25; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: cytosol

Molecular Function: adenylylsulfate kinase activity; ATP binding; sulfate adenylyltransferase (ATP) activity; nucleotidyltransferase activity

Biological Process: sulfate assimilation; glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; pathogenesis; blood coagulation; skeletal development; phosphorylation; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

Disease: Brachyolmia Type 4 With Mild Epiphyseal And Metaphyseal Changes
Product References and Citations for anti-PAPSS2 antibody
Xu, Z.H., et al., Biochem. Biophys. Res. Commun. 268(2):437-444 (2000).
Kurima, K., et al., J. Biol. Chem. 274(47):33306-33312 (1999).
ul Haque, M.F., et al., Nat. Genet. 20(2):157-162 (1998).
Kurima, K., et al., Proc. Natl. Acad. Sci. U.S.A. 95(15):8681-8685 (1998).
Shimizu, C., et al., Biochem. J. 363 (Pt 2), 263-271 (2002).

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Disclaimer
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