NP_002843.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,976 Da
NCBI Official Full Name
pentraxin-related protein PTX3
NCBI Official Synonym Full Names
pentraxin 3
NCBI Protein Information
pentraxin-related protein PTX3
UniProt Protein Name
Pentraxin-related protein PTX3
UniProt Synonym Protein Names
Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14
UniProt Synonym Gene Names
NCBI Summary for PTX3
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
UniProt Comments for PTX3
PTX3: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q25.32
Cellular Component: extracellular region; extracellular space
Molecular Function: complement component C1q binding; identical protein binding; protein binding; virion binding; zymosan binding
Biological Process: inflammatory response; innate immune response; negative regulation of virion penetration into host cell; neutrophil degranulation; opsonization; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; response to yeast
Research Articles on PTX3
Precautions
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Products associated with anti-PTX3 antibody
Diseases associated with anti-PTX3 antibody
Organs/Tissues associated with anti-PTX3 antibody
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