• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-PTRH2 antibody :: Rabbit anti-Human Peptidyl-tRNA hydrolase 2 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS1499421
Unit / Price
Scan QR to view Datasheet
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Peptidyl-tRNA hydrolase 2 (PTRH2), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Peptidyl-tRNA hydrolase 2, mitochondrial polyclonal Antibody(PTRH2)

Product Synonym Names
PTH 2; Bcl-2 inhibitor of transcription 1; PTRH2; BIT1; PTH2; CGI-147
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608625
3D Structure
ModBase 3D Structure for Q9Y3E5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Peptidyl-tRNA hydrolase 2, mitochondrial protein (40-179aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-324237 / sc-324239 / sc-133935
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PTRH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PTRH2 antibody
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
Applications Tested/Suitable for anti-PTRH2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PTRH2 antibody
Recommended dilution: WB:1:500-5000
IHC:1:20-1:200

Western Blot (WB) of anti-PTRH2 antibody
All lanes: Peptidyl-tRNA hydrolase 2, mitochondrial antibody at 4ug/ml
Lane 1:MM231 whole cell lysate
Lane 2:Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 19kDa
Observed band size: 19kDa

anti-PTRH2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PTRH2 antibody
Immunohistochemistry of paraffin-embedded human small intestine using MBS1499421 at dilution 1:100
anti-PTRH2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PTRH2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,194 Da
NCBI Official Full Name
peptidyl-tRNA hydrolase 2, mitochondrial isoform a
NCBI Official Synonym Full Names
peptidyl-tRNA hydrolase 2
NCBI Official Symbol
PTRH2  [Similar Products]
NCBI Official Synonym Symbols
PTH; BIT1; PTH2; PTH 2; CFAP37; IMNEPD; CGI-147
  [Similar Products]
NCBI Protein Information
peptidyl-tRNA hydrolase 2, mitochondrial
UniProt Protein Name
Peptidyl-tRNA hydrolase 2, mitochondrial
UniProt Synonym Protein Names
Bcl-2 inhibitor of transcription 1
Protein Family
UniProt Gene Name
PTRH2  [Similar Products]
UniProt Synonym Gene Names
BIT1; PTH2; PTH 2  [Similar Products]
UniProt Entry Name
PTH2_HUMAN
NCBI Summary for PTRH2
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
UniProt Comments for PTRH2
PTRH2: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. Monomer. Belongs to the PTH2 family.

Protein type: Mitochondrial; EC 3.1.1.29; Hydrolase

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: cytosol; membrane; mitochondrion

Molecular Function: aminoacyl-tRNA hydrolase activity; protein binding

Biological Process: apoptosis; metabolic process

Disease: Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-onset
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000