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anti-PTRH2 antibody :: Rabbit anti-Human Peptidyl-tRNA hydrolase 2 Polyclonal Antibody

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Catalog # MBS1499421
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Peptidyl-tRNA hydrolase 2 (PTRH2), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Peptidyl-tRNA hydrolase 2, mitochondrial polyclonal Antibody(PTRH2)

Product Synonym Names
PTH 2; Bcl-2 inhibitor of transcription 1; PTRH2; BIT1; PTH2; CGI-147
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y3E5
Species Reactivity
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recombinant human Peptidyl-tRNA hydrolase 2, mitochondrial protein (40-179aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-324237 / sc-324239 / sc-133935
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PTRH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PTRH2 antibody
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.
Applications Tested/Suitable for anti-PTRH2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PTRH2 antibody
Recommended dilution: WB:1:500-5000

Western Blot (WB) of anti-PTRH2 antibody
All lanes: Peptidyl-tRNA hydrolase 2, mitochondrial antibody at 4ug/ml
Lane 1:MM231 whole cell lysate
Lane 2:Jurkat whole cell lysate
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 19kDa
Observed band size: 19kDa

anti-PTRH2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PTRH2 antibody
Immunohistochemistry of paraffin-embedded human small intestine using MBS1499421 at dilution 1:100
anti-PTRH2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PTRH2. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,194 Da
NCBI Official Full Name
peptidyl-tRNA hydrolase 2, mitochondrial isoform a
NCBI Official Synonym Full Names
peptidyl-tRNA hydrolase 2
NCBI Official Symbol
PTRH2  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
peptidyl-tRNA hydrolase 2, mitochondrial
UniProt Protein Name
Peptidyl-tRNA hydrolase 2, mitochondrial
UniProt Synonym Protein Names
Bcl-2 inhibitor of transcription 1
Protein Family
UniProt Gene Name
PTRH2  [Similar Products]
UniProt Synonym Gene Names
BIT1; PTH2; PTH 2  [Similar Products]
UniProt Entry Name
NCBI Summary for PTRH2
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
UniProt Comments for PTRH2
PTRH2: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. Monomer. Belongs to the PTH2 family.

Protein type: Mitochondrial; EC; Hydrolase

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: cytosol; membrane; mitochondrion

Molecular Function: aminoacyl-tRNA hydrolase activity; protein binding

Biological Process: apoptosis; metabolic process

Disease: Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-onset
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