NP_038467.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,898 Da
NCBI Official Full Name
paired immunoglobulin-like type 2 receptor alpha isoform 1
NCBI Official Synonym Full Names
paired immunoglobin like type 2 receptor alpha
NCBI Official Synonym Symbols
NCBI Protein Information
paired immunoglobulin-like type 2 receptor alpha
UniProt Protein Name
Paired immunoglobulin-like type 2 receptor alpha
UniProt Synonym Protein Names
Cell surface receptor FDF03; Inhibitory receptor PILR-alpha
UniProt Entry Name
PILRA_HUMAN
NCBI Summary for PILRA
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
UniProt Comments for PILRA
PILRA: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to plasma membrane
Molecular Function: MHC class I protein binding; protein binding
Biological Process: signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
Research Articles on PILRA
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Products associated with anti-PILRA antibody
Pathways associated with anti-PILRA antibody
Diseases associated with anti-PILRA antibody
Organs/Tissues associated with anti-PILRA antibody
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