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anti-PPP1R14A antibody :: Rabbit anti-Human PPP1R14A Polyclonal Antibody

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Catalog # MBS7004210
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

PPP1R14A, Polyclonal Antibody

Popular Item
Full Product Name

PPP1R14A Antibody

Product Synonym Names
Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17; PPP1INL
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608153
3D Structure
ModBase 3D Structure for Q96A00
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human Protein phosphatase 1 regulatory subunit 14A protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17561 / sc-30927 / sc-30930 / sc-48406 / sc-25751
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PPP1R14A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PPP1R14A antibody
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Applications Tested/Suitable for anti-PPP1R14A antibody
ELISA (EIA), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-PPP1R14A antibody
Immunohistochemistry of paraffin-embedded human testis tissue using MBS7004210 at dilution of 1:100
anti-PPP1R14A antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PPP1R14A antibody
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7004210 at dilution of 1:100
anti-PPP1R14A antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PPP1R14A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,480 Da
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 14A isoform 2
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory inhibitor subunit 14A
NCBI Official Symbol
PPP1R14A  [Similar Products]
NCBI Official Synonym Symbols
CPI17; CPI-17; PPP1INL
  [Similar Products]
NCBI Protein Information
protein phosphatase 1 regulatory subunit 14A
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 14A
UniProt Synonym Protein Names
17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17
UniProt Gene Name
PPP1R14A  [Similar Products]
UniProt Synonym Gene Names
CPI17; PPP1INL; CPI-17  [Similar Products]
UniProt Entry Name
PP14A_HUMAN
NCBI Summary for PPP1R14A
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for PPP1R14A
PPP1R14A: a phosphorylation-dependent inhibitory subunit of protein phosphatase 1 (PP-1A). Phosphorylation by PKC regulates its binding to PP-1A. Acts co-operatively to inhibit myosin light chain phosphatase (MLCP) activity. Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2 ) concentration. Involved in the regulation of cell morphology, re-organisation of microfilaments, and cell spreading. Also expressed in human platelets and in brain where it may play a role in cerebellar long-term synaptic depression. Phosphorylation by ILK or Rho kinase enhances its ability to inhibit PP-1A.

Protein type: Inhibitor; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cytosol

Molecular Function: protein phosphatase inhibitor activity

Biological Process: negative regulation of catalytic activity; regulation of phosphorylation; small GTPase mediated signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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