NP_116222.4
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 78 Observed MW: 78
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 15B
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory subunit 15B
NCBI Official Synonym Symbols
NCBI Protein Information
protein phosphatase 1 regulatory subunit 15B
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 15B
UniProt Entry Name
PR15B_HUMAN
NCBI Summary for PPP1R15B
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
UniProt Comments for PPP1R15B
PPP1R15B: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Belongs to the PPP1R15 family.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: protein phosphatase type 1 complex
Molecular Function: protein binding; protein serine/threonine phosphatase activity
Biological Process: ER overload response; response to hydrogen peroxide
Research Articles on PPP1R15B
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Products associated with anti-PPP1R15B antibody
Organs/Tissues associated with anti-PPP1R15B antibody
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