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anti-PPP1R15B antibody :: Rabbit anti-Human PPP1R15B Polyclonal Antibody

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Catalog # MBS2537787
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

PPP1R15B, Polyclonal Antibody

Popular Item
Full Product Name

PPP1R15B Polyclonal Antibody

Product Synonym Names
PPP1R15B; Protein phosphatase 1 regulatory subunit 15B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2537787 Technical Datasheet
OMIM
613257
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity purification
Immunogen
Synthesized peptide derived from the Internal region of human PPP1R15B.
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-138534 / sc-138536
Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PPP1R15B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PPP1R15B antibody
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism.PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B) is a Protein Coding gene. Diseases associated with PPP1R15B include Microcephaly, Short Stature, And Impaired Glucose Metabolism 2 and Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome. GO annotations related to this gene include protein serine/threonine phosphatase activity.
Applications Tested/Suitable for anti-PPP1R15B antibody
WB,IHC-p,ELISA
Application Notes for anti-PPP1R15B antibody
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000-1:10000

Western Blot (WB) of anti-PPP1R15B antibody
Western Blot analysis of NIH-3T3 cells with PPP1R15B Polyclonal Antibody.
anti-PPP1R15B antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PPP1R15B antibody
Immunohistochemistry of paraffin-embedded Human liver tissue using PPP1R15B Polyclonal Antibody at dilution of 1:100.
anti-PPP1R15B antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PPP1R15B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 78
Observed MW: 78
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 15B
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory subunit 15B
NCBI Official Symbol
PPP1R15B  [Similar Products]
NCBI Official Synonym Symbols
CREP; MSSGM2
  [Similar Products]
NCBI Protein Information
protein phosphatase 1 regulatory subunit 15B
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 15B
UniProt Gene Name
PPP1R15B  [Similar Products]
UniProt Entry Name
PR15B_HUMAN
NCBI Summary for PPP1R15B
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
UniProt Comments for PPP1R15B
PPP1R15B: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Belongs to the PPP1R15 family.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: protein phosphatase type 1 complex

Molecular Function: protein binding; protein serine/threonine phosphatase activity

Biological Process: ER overload response; response to hydrogen peroxide
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-PPP1R15B antibody
Organs/Tissues associated with anti-PPP1R15B antibody
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