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anti-PPP1R8 antibody :: Rabbit anti-Human PPP1R8 Polyclonal Antibody

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Catalog # MBS7045769
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

PPP1R8, Polyclonal Antibody

Popular Item
Also Known As

PPP1R8 Antibody

Product Synonym Names
Nuclear inhibitor of protein phosphatase 1; NIPP-1; Protein phosphatase 1 regulatory inhibitor subunit 8; Activator of RNA decay; ARD-1; PPP1R8; ARD1; NIPP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
127
OMIM
602636
3D Structure
ModBase 3D Structure for Q12972
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Nuclear inhibitor of protein phosphatase 1 protein (1-209AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-67702 / sc-67703 / sc-67704 / sc-67705
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PPP1R8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PPP1R8 antibody
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Applications Tested/Suitable for anti-PPP1R8 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-PPP1R8 antibody
Western blot
All lanes: PPP1R8 antibody at 1.11 ug/ml
Lane 1: PC-3 whole cell lysate
Lane 2: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39,23,14 kDa
Observed band size: 38 kDa

anti-PPP1R8 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PPP1R8 antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7045769 at dilution 1:100
anti-PPP1R8 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PPP1R8 antibody
Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7045769 at dilution 1:100
anti-PPP1R8 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-PPP1R8 antibody
Immunofluorescent analysis of hepg2 using MBS7045769 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PPP1R8 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for PPP1R8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,344 Da
NCBI Official Full Name
nuclear inhibitor of protein phosphatase 1 isoform gamma
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory subunit 8
NCBI Official Symbol
PPP1R8  [Similar Products]
NCBI Official Synonym Symbols
ARD1; ARD-1; NIPP1; NIPP-1; PRO2047
  [Similar Products]
NCBI Protein Information
nuclear inhibitor of protein phosphatase 1
UniProt Protein Name
Nuclear inhibitor of protein phosphatase 1
UniProt Synonym Protein Names
Protein phosphatase 1 regulatory inhibitor subunit 8Including the following 1 domains:Activator of RNA decay (EC:3.1.4.-)Alternative name(s):ARD-1
UniProt Gene Name
PPP1R8  [Similar Products]
UniProt Synonym Gene Names
ARD1; NIPP1; NIPP-1  [Similar Products]
UniProt Entry Name
PP1R8_HUMAN
NCBI Summary for PPP1R8
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
UniProt Comments for PPP1R8
NIPP-1: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.-; Protein phosphatase, regulatory subunit; Inhibitor; Ribonuclease; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: nuclear speck; nucleoplasm; nucleus

Molecular Function: protein binding; ribonuclease E activity; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: RNA catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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