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anti-CHMP1A antibody :: Rabbit anti-Human Procollagen Type III Polyclonal Antibody

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Catalog # MBS316311
Unit / Price
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  0.1 mL  /  $785 +1 FREE 8GB USB
anti-CHMP1A antibody
Product Name

Procollagen Type III (CHMP1A), Polyclonal Antibody

Full Product Name

Rabbit A' Procollagen Type III

Product Synonym Names
Rabbit Antibody to Human Procollagen Type III
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (89710843..89724129, complement). Location: 16q24.3
OMIM
164010
3D Structure
ModBase 3D Structure for Q9HD42
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Procollagen Type III
Crossreactivity: (RIA%)
Human Procollagen, Type III - 100%
Human Procollagen, Type I - <0.1%
Bovine Procollagen, Types I - <0.1%
Bovine Procollagen, Type III - 100%
Purity/Purification
Ion exchange chromatography (DEAE-Trisacryl)
Form/Format
Purified, Lyophilized
Reconstitute with 0.5ml deionized water.
Concentration
Not determined
Titer: 1:10,000 (RIA) (lot specific)
Immunogen
Purified Procollagen Type III Amino terminal peptide (PIII NP)
Buffer
Not applicable
Preservative
No
Lyophilized
Yes
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Lyophilized: Short-term (up to 24 months) store at 2 to 8 degree C. Long term store at -20 degree C.
Reconstituted: Aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CHMP1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CHMP1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,703 Da[Similar Products]
NCBI Official Full Name
procollagen (type III) N-endopeptidase, isoform CRA_a
NCBI Official Synonym Full Names
chromatin modifying protein 1A
NCBI Official Symbol
CHMP1A  [Similar Products]
NCBI Official Synonym Symbols
CHMP1; PRSM1; PCOLN3; VPS46A; VPS46-1; KIAA0047
  [Similar Products]
NCBI Protein Information
charged multivesicular body protein 1a; protease, metallo, 1, 33kD; procollagen (type III) N-endopeptidase; vacuolar protein sorting-associated protein 46-1; charged multivesicular body protein 1/chromatin modifying protein 1
UniProt Protein Name
Charged multivesicular body protein 1a
UniProt Synonym Protein Names
Chromatin-modifying protein 1a; CHMP1a; Vacuolar protein sorting-associated protein 46-1
Protein Family
UniProt Gene Name
CHMP1A  [Similar Products]
UniProt Synonym Gene Names
CHMP1; KIAA0047; PCOLN3; PRSM1  [Similar Products]
UniProt Entry Name
CHM1A_HUMAN
NCBI Summary for CHMP1A
This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. [provided by RefSeq]
UniProt Comments for CHMP1A
Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. Ref.1 Ref.2 Ref.7 Ref.13

Subunit structure: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Ref.7 Ref.8 Ref.9 Ref.12 Ref.13

Subcellular location: Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note: The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin. Ref.2 Ref.7

Tissue specificity: Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG63. Ref.1

Induction: By muristerone. Ref.2

Sequence similarities: Belongs to the SNF7 family.

Caution: Was originally (Ref.1) thought to be a metalloprotease (PRSM1). This was based on a wrong translation of the ORF which gave rise to a putative protein of 318 AA containing a pattern reminiscent of zinc metalloproteases.

Sequence caution: The sequence AAC50775.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.The sequence BAA07557.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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