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anti-PRODH antibody :: Rabbit anti-Human PRODH Polyclonal Antibody

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Catalog # MBS7048939
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

PRODH, Polyclonal Antibody

Popular Item
Full Product Name

PRODH Antibody

Product Synonym Names
Proline dehydrogenase 1; mitochondrial; Proline oxidase; Proline oxidase 2; p53-induced gene 6 protein; PRODH; PIG6; POX2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U82381 mRNA
3D Structure
ModBase 3D Structure for O43272
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Proline dehydrogenase 1, mitochondrial protein (71-134AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79583 / sc-79585 / sc-98682
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PRODH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PRODH antibody
Converts proline to delta-1-pyrroline-5-carboxylate.
Applications Tested/Suitable for anti-PRODH antibody
ELISA (EIA)

Western Blot (WB) of anti-PRODH antibody
Western Blot
Positive WB detected in: Rat liver tissue
All lanes: PRODH antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69,57,60 KDa
Observed band size: 69 KDa

anti-PRODH antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PRODH antibody
IHC image of MBS7048939 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
anti-PRODH antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PRODH antibody
IHC image of MBS7048939 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
anti-PRODH antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PRODH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,231 Da
NCBI Official Full Name
proline dehydrogenase 1, mitochondrial isoform 2
NCBI Official Synonym Full Names
proline dehydrogenase 1
NCBI Official Symbol
PRODH  [Similar Products]
NCBI Official Synonym Symbols
POX; PIG6; HSPOX2; PRODH1; PRODH2; TP53I6
  [Similar Products]
NCBI Protein Information
proline dehydrogenase 1, mitochondrial
UniProt Protein Name
Proline dehydrogenase 1, mitochondrial
UniProt Synonym Protein Names
Proline oxidase; Proline oxidase 2; p53-induced gene 6 protein
UniProt Gene Name
PRODH  [Similar Products]
UniProt Synonym Gene Names
PIG6; POX2  [Similar Products]
UniProt Entry Name
PROD_HUMAN
NCBI Summary for PRODH
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
UniProt Comments for PRODH
PRODH: Converts proline to delta-1-pyrroline-5-carboxylate. Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1). HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Belongs to the proline oxidase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - arginine and proline; EC 1.5.5.2; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: mitochondrial inner membrane; mitochondrion

Molecular Function: proline dehydrogenase activity

Biological Process: 4-hydroxyproline catabolic process; proline catabolic process; proline catabolic process to glutamate; proline metabolic process

Disease: Hyperprolinemia, Type I; Schizophrenia 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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