NP_001191382.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,274 Da
NCBI Official Full Name
26S proteasome regulatory subunit 7 isoform 2
NCBI Official Synonym Full Names
proteasome 26S subunit, ATPase 2
NCBI Protein Information
26S proteasome regulatory subunit 7; 26S protease regulatory subunit 7
UniProt Protein Name
26S proteasome regulatory subunit 7
UniProt Synonym Protein Names
26S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2; Protein MSS1
UniProt Synonym Gene Names
NCBI Summary for PSMC2
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
UniProt Comments for PSMC2
RPT1: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation. Belongs to the AAA ATPase family.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; extracellular region; ficolin-1-rich granule lumen; membrane; nucleoplasm; nucleus; P-body; proteasome complex; proteasome regulatory particle, base subcomplex; secretory granule lumen
Molecular Function: ATP binding; ATPase activity; proteasome-activating ATPase activity; protein binding; TATA-binding protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ER-associated protein catabolic process; Fc-epsilon receptor signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; neutrophil degranulation; NIK/NF-kappaB signaling; osteoblast differentiation; positive regulation of canonical Wnt signaling pathway; positive regulation of transcriptional preinitiation complex assembly; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; post-translational protein modification; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mRNA stability; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; ubiquitin-dependent protein catabolic process; viral process; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMC2
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Products associated with anti-PSMC2 antibody
Pathways associated with anti-PSMC2 antibody
Diseases associated with anti-PSMC2 antibody
Organs/Tissues associated with anti-PSMC2 antibody
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