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anti-PADI2 antibody :: Rabbit anti-Human Protein-arginine deiminase type-2 Polyclonal Antibody

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Catalog # MBS7000390
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

Protein-arginine deiminase type-2 (PADI2), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Protein-arginine deiminase type-2 polyclonal Antibody

Product Synonym Names
PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607935
3D Structure
ModBase 3D Structure for Q9Y2J8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human Protein-arginine deiminase type-2 protein(1-665aa)
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48620 / sc-133877
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PADI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PADI2 antibody
Catalyzes the deimination of arginine residues of proteins.

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
Applications Tested/Suitable for anti-PADI2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PADI2 antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-PADI2 antibody
Western blot
All lanes: Protein-arginine deiminase type-2 antibody at 20ug/ml
Lane 1: Hela whole cell lysate
Lane 2: Mouse brain tissue
Lane 3: MDA-MB-231 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 76,50 kDa
Observed band size: 76 kDa

anti-PADI2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PADI2 antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS7000390 at dilution 1:100
anti-PADI2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PADI2 antibody
Immunohistochemistry of paraffin-embedded human liver using MBS7000390 at dilution 1:100
anti-PADI2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-PADI2 antibody
Western Blot
Positive WB detected in: Rat brain tissue,Mouse brain tissue
All lanes: PADI2 antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76,50 KDa
Observed band size: 76 KDa

anti-PADI2 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-PADI2 antibody
Immunofluorescent analysis of PC3 cells using MBS7000390 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PADI2 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for PADI2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,310 Da
NCBI Official Full Name
protein-arginine deiminase type-2
NCBI Official Synonym Full Names
peptidyl arginine deiminase, type II
NCBI Official Symbol
PADI2  [Similar Products]
NCBI Official Synonym Symbols
PAD2; PDI2; PAD-H19
  [Similar Products]
NCBI Protein Information
protein-arginine deiminase type-2
UniProt Protein Name
Protein-arginine deiminase type-2
UniProt Synonym Protein Names
PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II
UniProt Gene Name
PADI2  [Similar Products]
UniProt Synonym Gene Names
KIAA0994; PAD2; PDI2  [Similar Products]
UniProt Entry Name
PADI2_HUMAN
NCBI Summary for PADI2
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
UniProt Comments for PADI2
PADI2: Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family.

Protein type: EC 3.5.3.15; Hydrolase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytoplasm

Molecular Function: calcium ion binding; estrogen receptor binding; protein-arginine deiminase activity

Biological Process: chromatin-mediated maintenance of transcription; estrogen receptor signaling pathway; peptidyl-citrulline biosynthetic process from peptidyl-arginine; substantia nigra development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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