NP_001243264.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,943 Da
NCBI Official Full Name
prostaglandin E synthase 2 isoform 2
NCBI Official Synonym Full Names
prostaglandin E synthase 2
NCBI Official Synonym Symbols
GBF1; GBF-1; PGES2; C9orf15; mPGES-2 [Similar Products]
NCBI Protein Information
prostaglandin E synthase 2
UniProt Protein Name
Prostaglandin E synthase 2
UniProt Synonym Protein Names
Membrane-associated prostaglandin E synthase-2
UniProt Synonym Gene Names
UniProt Entry Name
PGES2_HUMAN
NCBI Summary for PTGES2
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Comments for PTGES2
PTGES2: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. Belongs to the GST superfamily.
Protein type: EC 5.3.99.3; Lipid Metabolism - arachidonic acid; Isomerase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: mitochondrion
Molecular Function: glutathione binding; heme binding; lyase activity; protein binding
Research Articles on PTGES2
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Pathways associated with anti-PTGES2 antibody
Diseases associated with anti-PTGES2 antibody
Organs/Tissues associated with anti-PTGES2 antibody
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