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anti-Rab8 antibody :: Rabbit anti-Human Rab8 Polyclonal Antibody

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Catalog # MBS620263
Unit / Price
  0.1 mL  /  $480 +1 FREE 8GB USB
anti-Rab8 antibody
Product Name

Rab8, Polyclonal Antibody

Also Known As

Rab8

Product Synonym Names
Anti -Rab8
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 3L; NT_037436.3 (19860588..19864157, complement). Location: 76D2-76D3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Recognizes human Rab8. Species crossreactivity: mouse, rat, monkey.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied in 10mM sodium HEPES (pH 7.5), 150mM NaCl, 100ug/ml BSA and 50% glycerol.
Immunogen
Synthetic peptide corresponding to residues surrounding Met173 of human Rab8 protein (KLH-coupled).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-Rab8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Rab8 antibody
The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring (1). Studies show that Rab8 is localized to the trans Golgi network (TGN), basolateral membrane and vesicular structures where it helps regulate target protein transport between TGN and the basolateral membrane (1-3). Overexpression studies and mutation analysis of Rab8 and its associated Rab8GEF indicate additional roles in actin and microtubule remodeling during polarized membrane transport and membrane protrusion formation (4-6). Rab8 associates with myosin Vb and is required for translocation of GLUT4 following insulin stimulation in muscle (7,8). Control of target protein vesicle transport by Rab8 also regulates MT1-MMP activity during extracellular matrix formation and JRAB/MICAL-L2 at tight junction formation (9,10).
Applications Tested/Suitable for anti-Rab8 antibody
Western Blot (WB)
Application Notes for anti-Rab8 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1%
Tween-20 at 4 degree C with gentle shaking, overnight.
NCBI/Uniprot data below describe general gene information for Rab8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
Rab-protein 8
NCBI Official Synonym Full Names
Rab-protein 8
NCBI Official Symbol
NCBI Official Synonym Symbols
AAF49101; CG8287; Dm Rab8; dm-Rab8; DmelCG8287; DmRab8; DRab8; DRAB8; Rab-r8; rab8
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NCBI Protein Information
CG8287 gene product from transcript CG8287-RA; Rab-protein 8; CG8287-PA; Rab8-PA
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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