Q92878
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Rad50
NCBI Official Synonym Full Names
RAD50 homolog (S. cerevisiae)
NCBI Protein Information
DNA repair protein RAD50; OTTHUMP00000065927
UniProt Protein Name
DNA repair protein RAD50
UniProt Entry Name
RAD50_HUMAN
NCBI Summary for RAD50
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
UniProt Comments for RAD50
RAD50: a component of the Mre11-Rad50-NBS1 (MRN) complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Three alternatively spliced isoforms have been described.
Protein type: EC 3.6.-.-; DNA repair, damage; Hydrolase; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: nucleoplasm; Mre11 complex; nuclear chromosome, telomeric region; membrane; pronucleus
Molecular Function: protein binding, bridging; ATP-dependent DNA helicase activity; protein binding; DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; metal ion binding; 3'-5' exonuclease activity; ATP binding
Biological Process: meiotic recombination; double-strand break repair; positive regulation of kinase activity; telomere maintenance via telomerase; DNA repair; regulation of mitotic recombination; telomere maintenance; response to DNA damage stimulus; DNA catabolic process, endonucleolytic; positive regulation of protein amino acid autophosphorylation; DNA duplex unwinding; double-strand break repair via homologous recombination; DNA recombination
Disease: Nijmegen Breakage Syndrome-like Disorder
Research Articles on RAD50
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-RAD50 antibody
Pathways associated with anti-RAD50 antibody
Diseases associated with anti-RAD50 antibody
Organs/Tissues associated with anti-RAD50 antibody
|