NP_001273602.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,060 Da
NCBI Official Full Name
regulator of G-protein signaling 20 isoform c
NCBI Official Synonym Full Names
regulator of G-protein signaling 20
NCBI Protein Information
regulator of G-protein signaling 20
UniProt Protein Name
Regulator of G-protein signaling 20
UniProt Synonym Protein Names
Gz-selective GTPase-activating protein; G(z)GAP; Gz-GAP; Regulator of G-protein signaling Z1; Regulator of Gz-selective protein signaling 1
UniProt Synonym Gene Names
UniProt Entry Name
RGS20_HUMAN
NCBI Summary for RGS20
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for RGS20
RGS20: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, misc.; GAPs
Chromosomal Location of Human Ortholog: 8q11.23
Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; nucleus; plasma membrane; postsynaptic density; trans-Golgi network
Molecular Function: beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding
Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; positive regulation of GTPase activity; regulation of G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent
Research Articles on RGS20
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Products associated with anti-RGS20 antibody
Pathways associated with anti-RGS20 antibody
Diseases associated with anti-RGS20 antibody
Organs/Tissues associated with anti-RGS20 antibody
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