NP_001265656.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,652 Da
NCBI Official Full Name
DNA-binding protein RFXANK isoform c
NCBI Official Synonym Full Names
regulatory factor X associated ankyrin containing protein
NCBI Protein Information
DNA-binding protein RFXANK
UniProt Protein Name
DNA-binding protein RFXANK
UniProt Synonym Protein Names
Ankyrin repeat family A protein 1; Regulatory factor X subunit B; RFX-B; Regulatory factor X-associated ankyrin-containing protein
UniProt Synonym Gene Names
NCBI Summary for RFXANK
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]
UniProt Comments for RFXANK
Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 ().
Research Articles on RFXANK
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Products associated with anti-RFXANK antibody
Pathways associated with anti-RFXANK antibody
Diseases associated with anti-RFXANK antibody
Organs/Tissues associated with anti-RFXANK antibody
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