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anti-RARRES3 antibody :: Goat RIG1/RARRES3 Polyclonal Antibody

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Catalog # MBS421596
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
anti-RARRES3 antibody
Product Name

RIG1/RARRES3, Polyclonal Antibody

Full Product Name

Goat anti-RIG1/RARRES3 (aa 124 to 136) Antibody

Product Synonym Names
Goat Anti-RIG1 / RARRES3 (aa 119 to 134) Antibody; RARRES3; retinoic acid receptor responder (tazarotene induced) 3; HRASLS4; MGC8906; RIG1; TIG3; RARRES3 antibody; retinoic acid receptor responder (tazarotene induced) 3 antibody; HRASLS4 antibody; MGC8906 antibody; RIG1 antibody; TIG3 antibody; RIG1 / RARRES3 (aa 124 to 136)
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
KSRCKQVEKA KVE
OMIM
605092
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence KSRCKQVEKAKVE, from the internal region of the protein sequence according to NP_004576.2.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-RARRES3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RARRES3 antibody
Peptide ELISA (EIA)
Application Notes for anti-RARRES3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Preliminary experiments gave bands at approx 22kDa and 55kDa in Human Thymus lysates after 1ug/ml antibody staining. The 55kDa band was observed in all tissues tested. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 18.8kDa according to NP_004576.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
NCBI/Uniprot data below describe general gene information for RARRES3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,436 Da
NCBI Official Full Name
retinoic acid receptor responder protein 3
NCBI Official Synonym Full Names
retinoic acid receptor responder 3
NCBI Official Symbol
RARRES3  [Similar Products]
NCBI Official Synonym Symbols
RIG1; TIG3; HRSL4; HRASLS4; PLA1/2-3
  [Similar Products]
NCBI Protein Information
retinoic acid receptor responder protein 3
UniProt Protein Name
Retinoic acid receptor responder protein 3
UniProt Synonym Protein Names
HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoid-inducible gene 1 protein; Tazarotene-induced gene 3 protein
UniProt Gene Name
RARRES3  [Similar Products]
UniProt Synonym Gene Names
RIG1; TIG3; HRSL4  [Similar Products]
UniProt Entry Name
HRSL4_HUMAN
NCBI Summary for RARRES3
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
UniProt Comments for RARRES3
RARRES3: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. Belongs to the H-rev107 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.-; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: integral to membrane

Molecular Function: phospholipase A2 activity; protein binding

Biological Process: lipid catabolic process; negative regulation of cell proliferation; phospholipid metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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