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anti-RNF6 antibody :: Rabbit anti-Human RNF6 Polyclonal Antibody

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Catalog # MBS9609207
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

RNF6, Polyclonal Antibody

Popular Item
Also Known As

RNF6 Antibody

Product Synonym Names
E3 ubiquitin-protein ligase RNF6; Ring finger protein (C3H2C3 type) 6; Ring finger protein 6; RING H2 protein; RING H2 protein RNF6; RNF 6; RNF6; RNF6_HUMAN; SPG2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
685
3D Structure
ModBase 3D Structure for Q9Y252
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
RNF6 antibody detects endogenous levels of total RNF6
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human RNF6
Subcellular Location
Nucleus. Cytoplasm. Cell Projection > Axon. Nucleus > PML Body. Localizes to the PML nuclear bodies in Sertoli cells.
Tissue Specificity
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-RNF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RNF6 antibody
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Subunit Structure: Interacts with LIMK1 (By similarity). Interacts with AR.
Similarity: Belongs to the RNF12 family.
Applications Tested/Suitable for anti-RNF6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-RNF6 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-RNF6 antibody
Western blot analysis of RNF6 using MCF7 whole cell lysates
anti-RNF6 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-RNF6 antibody
Western blot analysis of extracts from various samples, using RNF6 Antibody. Lane 1: hela treated with blocking peptide. Lane 2: Hela; Lane 3: Hepg2;
anti-RNF6 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for RNF6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 78 kDa
Predicted: 79 kDa
NCBI Official Full Name
E3 ubiquitin-protein ligase RNF6 isoform 1
NCBI Official Synonym Full Names
ring finger protein 6
NCBI Official Symbol
NCBI Protein Information
E3 ubiquitin-protein ligase RNF6
UniProt Protein Name
E3 ubiquitin-protein ligase RNF6
UniProt Synonym Protein Names
RING-type E3 ubiquitin transferase RNF6Curated
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for RNF6
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
UniProt Comments for RNF6
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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