NP_037479.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
replication protein A 30 kDa subunit
NCBI Official Synonym Full Names
replication protein A4, 30kDa
NCBI Official Synonym Symbols
NCBI Protein Information
replication protein A 30 kDa subunit
UniProt Protein Name
Replication protein A 30 kDa subunit
UniProt Synonym Protein Names
Replication factor A protein 4; RF-A protein 4
UniProt Synonym Gene Names
UniProt Entry Name
RFA4_HUMAN
NCBI Summary for RPA4
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
UniProt Comments for RPA4
RPA4: functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Component of the alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. Interacts with RPA1 and RPA3. Localizes to DNA repair foci after DNA damage.
Chromosomal Location of Human Ortholog: Xq21.33
Cellular Component: nucleoplasm; DNA replication factor A complex; nucleus
Molecular Function: single-stranded DNA binding
Biological Process: DNA replication initiation; nucleotide-excision repair; DNA damage checkpoint; DNA replication during S phase; mitotic cell cycle; DNA recombination; G1/S transition of mitotic cell cycle
Product References and Citations for anti-RPA4 antibody
Kemp, M.G., et al. J. Biol. Chem. 285(7):4788-4797(2010) Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010) Haring, S.J., et al. Nucleic Acids Res. 38(3):846-858(2010) Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009) Mason, A.C., et al. J. Biol. Chem. 284(8):5324-5331(2009)
Research Articles on RPA4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-RPA4 antibody
Diseases associated with anti-RPA4 antibody
|