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anti-RUNX1T1 antibody :: Rabbit anti-Human RUNX1T1 Polyclonal Antibody

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Catalog # MBS7045567
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

RUNX1T1, Polyclonal Antibody

Popular Item
Full Product Name

RUNX1T1 Antibody

Product Synonym Names
Protein CBFA2T1; Cyclin-D-related protein; Eight twenty one protein; Protein ETO; Protein MTG8; Zinc finger MYND domain-containing prote; RUNX1T1; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
133435
3D Structure
ModBase 3D Structure for Q06455
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Protein CBFA2T1 protein
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9737 / sc-9736 / sc-28693
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-RUNX1T1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RUNX1T1 antibody
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity).
Applications Tested/Suitable for anti-RUNX1T1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-RUNX1T1 antibody
Western Blot
Positive WB detected in:HepG2 whole cell lysate,Jurkat whole cell lysate
All lanes: RUNX1T1 antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 68,65,69,64,49,45 kDa
Observed band size: 68 kDa

anti-RUNX1T1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-RUNX1T1 antibody
Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7045567 at dilution of 1:100
anti-RUNX1T1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for RUNX1T1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,212 Da
NCBI Official Full Name
protein CBFA2T1 isoform A
NCBI Official Synonym Full Names
RUNX1 translocation partner 1
NCBI Official Symbol
RUNX1T1  [Similar Products]
NCBI Official Synonym Symbols
CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8
  [Similar Products]
NCBI Protein Information
protein CBFA2T1
UniProt Protein Name
Protein CBFA2T1
UniProt Synonym Protein Names
Cyclin-D-related protein; Eight twenty one protein; Protein ETO; Protein MTG8; Zinc finger MYND domain-containing protein 2
Protein Family
UniProt Gene Name
RUNX1T1  [Similar Products]
UniProt Synonym Gene Names
AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2  [Similar Products]
UniProt Entry Name
MTG8_HUMAN
NCBI Summary for RUNX1T1
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
UniProt Comments for RUNX1T1
RUNX1T1: Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. Belongs to the CBFA2T family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription regulation

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: cytoplasm; mitochondrion; nuclear matrix; nucleoplasm

Molecular Function: protein binding; transcription corepressor activity

Biological Process: generation of precursor metabolites and energy; negative regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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