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anti-SCN5A antibody :: Goat SCN5A Polyclonal Antibody

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Catalog # MBS422777
Unit / Price
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  0.1 mg  /  $225 +1 FREE 8GB USB
anti-SCN5A antibody
Product Name

SCN5A, Polyclonal Antibody

Full Product Name

Goat anti-SCN5A (aa1021-1034) Antibody

Product Synonym Names
Goat Anti-SCN5A Antibody; SCN5A; sodium channel, voltage-gated, type V, alpha subunit; CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1; OTTHUMP00000209279; OTTHUMP00000209280; OTTHUMP00000209281; OTTHUMP00000209282; OTTHUMP00000209283; OTTHUMP00; SCN5A antibody; sodium channel; voltage-gated; type V; alpha subunit antibody; CDCD2 antibody; CMD1E antibody; CMPD2 antibody; HB1 antibody; HB2 antibody; HBBD antibody; HH1 antibody; IVF antibody; LQT3 antibody; Nav1.5 antibody; PFHB1 antibody; SSS1 antibody; VF1 antibody; OTTHUMP00000209279 antibody; SCN5A (aa1021-1034)
Antibody/Peptide Pairs
SCN5A peptide (MBS427706) is used for blocking the activity of SCN5A antibody (MBS422777)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
PTRKETRFEE GEQP
OMIM
108770
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PTRKETRFEEGEQP, from the internal region of the protein sequence according to NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1.
Epitope
Internal region
Note
This antibody is expected to recognize all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-SCN5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SCN5A antibody
Peptide ELISA (EIA)
Application Notes for anti-SCN5A antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Preliminary experiments gave an approx 80kDa band in HeLa lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 227kDa according to NP_932173.1. The 80kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for SCN5A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
224,917 Da
NCBI Official Full Name
sodium channel protein type 5 subunit alpha isoform a
NCBI Official Synonym Full Names
sodium voltage-gated channel alpha subunit 5
NCBI Official Symbol
SCN5A  [Similar Products]
NCBI Official Synonym Symbols
HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5
  [Similar Products]
NCBI Protein Information
sodium channel protein type 5 subunit alpha
UniProt Protein Name
Sodium channel protein type 5 subunit alpha
UniProt Synonym Protein Names
HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5
Protein Family
UniProt Gene Name
SCN5A  [Similar Products]
UniProt Entry Name
SCN5A_HUMAN
NCBI Summary for SCN5A
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for SCN5A
SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, sodium

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: caveola; cell surface; endoplasmic reticulum; integral to membrane; intracellular; lateral plasma membrane; plasma membrane; sarcolemma; T-tubule; voltage-gated sodium channel complex; Z disc

Molecular Function: ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity

Biological Process: cardiac muscle contraction; cerebellum development; generation of action potential; membrane depolarization; odontogenesis of dentine-containing teeth; positive regulation of action potential; positive regulation of epithelial cell proliferation; regulation of heart rate; regulation of postsynaptic membrane potential; response to denervation involved in regulation of muscle adaptation; sodium ion transport; telencephalon development

Disease: Atrial Fibrillation, Familial, 10; Brugada Syndrome 1; Cardiomyopathy, Dilated, 1e; Long Qt Syndrome 3; Progressive Familial Heart Block, Type Ia; Sick Sinus Syndrome 1, Autosomal Recessive; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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