NP_058544.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,939 Da
NCBI Official Full Name
SHC-transforming protein 3
NCBI Official Synonym Full Names
SHC adaptor protein 3
NCBI Protein Information
SHC-transforming protein 3
UniProt Protein Name
SHC-transforming protein 3
UniProt Synonym Protein Names
Neuronal Shc; N-Shc; Protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3; SH2 domain protein C3
UniProt Synonym Gene Names
UniProt Comments for SHC3
SHC3: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q22.1
Cellular Component: cytosol; plasma membrane
Molecular Function: phosphotyrosine binding; protein binding; Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding; signal transducer activity
Biological Process: axon guidance; central nervous system development; epidermal growth factor receptor signaling pathway; learning and/or memory; MAPK cascade; Ras protein signal transduction; regulation of molecular function; synaptic transmission, glutamatergic; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on SHC3
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